ArticleProceedings of the National Academy of Sciences of the United States of America1992
Myb and Ets proteins cooperate in transcriptional activation of the mim-1 promoter.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- MYB oncoproteins: emerging players and potential therapeutic targets in human cancer.Oncogenesis · 2021Review
- Systematic discovery and characterization of regulatory motifs in ENCODE TF binding experiments.Nucleic acids research · 2014Article
- Pax7 is regulated by cMyb during early neural crest development through a novel enhancer.Development (Cambridge, England) · 2013Article
- c-Myb regulates cell cycle-dependent expression of Erbin: an implication for a novel function of Erbin.PloS one · 2012Article
- Regulation of endothelial cell development by ETS transcription factors.Seminars in cell & developmental biology · 2011Review
- Regulation of cyst wall protein promoters by Myb2 in Giardia lamblia.The Journal of biological chemistry · 2008Article
- c-Myb oncoprotein is an essential target of the dleu2 tumor suppressor microRNA cluster.Cancer biology & therapy · 2008Article
- Differential modulation of Myb family genes by Ets-2.Oncogene · 2004Article
- Molecular mechanisms associated with the regulation of apoptosis by the two alternatively spliced products of c-Myb.Molecular and cellular biology · 2003Article
- The biology of the Ets1 proto-oncogene.Molecular cancer · 2003Review
- Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma.Oncogene · 2003Article
- Review
- Review
- c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation.Molecular and cellular biology · 1998Article
- A role for CREB binding protein and p300 transcriptional coactivators in Ets-1 transactivation functions.Molecular and cellular biology · 1998Article
- CBF, Myb, and Ets binding sites are important for activity of the core I element of the murine retrovirus SL3-3 in T lymphocytes.Journal of virology · 1998Article
- The C-terminal domain of B-Myb acts as a positive regulator of transcription and modulates its biological functions.Molecular and cellular biology · 1998Article
- Core binding factor cannot synergistically activate the myeloperoxidase proximal enhancer in immature myeloid cells without c-Myb.Molecular and cellular biology · 1997Article
- c-Myb and Ets proteins synergize to overcome transcriptional repression by ZEB.The EMBO journal · 1997Article
- A-myb is expressed in bovine vascular smooth muscle cells during the late G1-to-S phase transition and cooperates with c-myc to mediate progression to S phase.Molecular and cellular biology · 1997Article
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Authors and funding
5 authors.
Funding
Abstract
In the generation of the acutely transforming avian retrovirus E26, both myb and ets genes have been transduced, leading to the production of a Gag-Myb-Ets fusion protein. This co-occurrence of v-myb and v-ets oncogenes suggests that the two might have a functional relationship. To look for such a relationship, we tested the transcriptional activation activity of Myb alone or with coexpressed Ets-1 or Ets-2. Using the promoter of the v-Myb-inducible mim-1 gene as a target, we found that full-length c-Myb gene products were poor activators of transcription, while an oncogenic (truncated) form of this protein was a strong trans-activator. However, coexpression of Ets-2 with full-length or truncated forms of Myb greatly increased trans-activation. Coexpression of Ets-1, Fos, Jun, or Myc with Myb did not increase trans-activation of the mim-1 promoter. The ability of Myb and Ets-2 to transactivate was cooperative, since Ets-2 alone gave little or no activation. Bacterially synthesized Ets-2 protein was found to bind specifically to the mim-1 promoter, suggesting that it may be a target for both Myb and Ets proteins. Thus, Myb and Ets proteins can cooperate in transcriptional activation, and their co-occurrence in the E26 virus may reflect a functional relationship between these two oncoproteins. Truncated forms of Myb may have a reduced need for cooperating factors such as Ets-2, and this might constitute an important mechanism associated with oncogenic activation.
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