Evidence map›Paper›PMID 17413096›Full record

Trial reportThe American journal of clinical nutrition2007

A controlled trial of reduced meal frequency without caloric restriction in healthy, normal-weight, middle-aged adults.

Kim S Stote, David J Baer, Karen Spears, David R Paul, G Keith Harris, William V Rumpler, Pilar Strycula, Samer S Najjar, Luigi Ferrucci, Donald K Ingram and 2 more

3 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 196 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
196citing papers in PubMed, 19 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03940482 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Time Restricted Eating As Treatment (TREAT) for Diabetes Mellitus: A Pre-Post 12 Week Study on the Effectiveness of Intermittent Fasting in Asians With Type 2 Diabetes Mellitus

TypeinterventionalSponsorSingapore General HospitalRan2019 to 2023Enrolled50ConditionsType 2 Diabetes MellitusArmsTime Restricted Eating As Treatment (TREAT) for Diabetes.
NCT04102657 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Blood Glucose Differences Between Left Arm and Right Arm Using a Continuous Glucose

TypeinterventionalSponsorUniversity of the PacificRan2019 to 2019Enrolled46ConditionsDiabetesArmsIntermittent Fasting, Free-Living Diet, Left Arm Exercise, Right Arm Exercise
NCT06163248 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Effect of a Chrono Nutrition Intervention on Insulin Resistance in Adults With Type 2 Diabetes

TypeinterventionalSponsorInstituto Nacional de Ciencias Medicas y Nutricion Salvador ZubiranRan2024 to 2026Enrolled40ConditionsDiabetes Mellitus, Type 2ArmsChrono nutrition, Standard
3 · Its place in the literature

Who cites it

196 citing papers in PubMed, 19 syntheses or guidelines pooled it, 400 citations in OpenAlex.

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136 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Kim S StoteBeltsville Human Nutrition Research Center, US Department of Agriculture, Agriculture Research Service, Beltsville, MD, USA.
David J Baer
Karen Spears
David R Paul
G Keith Harris
William V Rumpler
Pilar Strycula
Samer S Najjar
Luigi Ferrucci
Donald K Ingram
Dan L Longo
Mark P Mattson
United States Department of Agriculture · USBeltsville Human Nutrition Research Center · US

Funding

Dietary Modification Of Brain Aging /NeurodegenerativeZ01AG000315 · NIA · NATIONAL INSTITUTE ON AGING · PI MATTSON, MARK P · 2001 to 2008
$2.0M
Intramural NIH HHS Z99 AG999999
6 · The paper itself

Abstract

backgroundAlthough consumption of 3 meals/d is the most common pattern of eating in industrialized countries, a scientific rationale for this meal frequency with respect to optimal health is lacking. A diet with less meal frequency can improve the health and extend the lifespan of laboratory animals, but its effect on humans has never been tested.

objectiveA pilot study was conducted to establish the effects of a reduced-meal-frequency diet on health indicators in healthy, normal-weight adults.

designThe study was a randomized crossover design with two 8-wk treatment periods. During the treatment periods, subjects consumed all of the calories needed for weight maintenance in either 3 meals/d or 1 meal/d.

resultsSubjects who completed the study maintained their body weight within 2 kg of their initial weight throughout the 6-mo period. There were no significant effects of meal frequency on heart rate, body temperature, or most of the blood variables measured. However, when consuming 1 meal/d, subjects had a significant increase in hunger; a significant modification of body composition, including reductions in fat mass; significant increases in blood pressure and in total, LDL-, and HDL-cholesterol concentrations; and a significant decrease in concentrations of cortisol.

conclusionsNormal-weight subjects are able to comply with a 1 meal/d diet. When meal frequency is decreased without a reduction in overall calorie intake, modest changes occur in body composition, some cardiovascular disease risk factors, and hematologic variables. Diurnal variations may affect outcomes.

Indexed as

Adipose TissueAdultAnalysis of VarianceBiomarkersBlood Chemical AnalysisBlood PressureBody CompositionCholesterolCircadian RhythmCross-Over StudiesEatingEnergy IntakeFemaleHumansHungerHydrocortisoneBiomarkersCholesterolHydrocortisone

Identifiers

PMID17413096
PMCPMC2645638
OpenAlexW2129074350

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.