ArticleScience (New York, N.Y.)2007
An ATP gate controls tubulin binding by the tethered head of kinesin-1.
Article in Science (New York, N.Y.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 119 citations in OpenAlex.
- ATPγS substantially defeats the biasing mechanism for kinesin steps.Nature communications · 2026Article
- An Overview of Contrasting Experimental Results on Dynamics of Kinesin-1 Molecular Motors: Insight into the Underlying Mechanism.Biomolecules · 2025Review
- Factors Determining Kinesin Motors in a Predominant One-Head-Bound or Two-Heads-Bound State During Its Stepping Cycle.Biomolecules · 2025Article
- Tether-scanning the kinesin motor domain reveals a core mechanical action.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Microtubule Regulation in Plants: From Morphological Development to Stress Adaptation.Biomolecules · 2023Review
- Reconstituting Microtubules: A Decades-Long Effort From Building Block Identification to the Generation of Recombinant α/β-Tubulin.Frontiers in cell and developmental biology · 2022Review
- Backstepping Mechanism of Kinesin-1.Biophysical journal · 2020Article
- These motors were made for walking.Protein science : a publication of the Protein Society · 2020Review
- A Generalized Kinetic Model for Coupling between Stepping and ATP Hydrolysis of Kinesin Molecular Motors.International journal of molecular sciences · 2019Article
- Processivity of dimeric kinesin-1 molecular motors.FEBS open bio · 2018Article
- Kinesin expands and stabilizes the GDP-microtubule lattice.Nature nanotechnology · 2018Article
- Article
- A Tubulin Binding Switch Underlies Kip3/Kinesin-8 Depolymerase Activity.Developmental cell · 2017Article
- Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin.Nature communications · 2017Article
- Kinesin Processivity Is Determined by a Kinetic Race from a Vulnerable One-Head-Bound State.Biophysical journal · 2017Article
- Expression and functional analyses of a Kinesin gene GhKIS13A1 from cotton (Gossypium hirsutum) fiber.BMC biotechnology · 2017Article
- Design principles governing chemomechanical coupling of kinesin.Scientific reports · 2017Article
- Crystal structure of Zen4 in the apo state reveals a missing conformation of kinesin.Nature communications · 2017Article
- Review: Mechanochemistry of the kinesin-1 ATPase.Biopolymers · 2016Review
- Direct observation of intermediate states during the stepping motion of kinesin-1.Nature chemical biology · 2016Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Kinesin-1 is a two-headed molecular motor that walks along microtubules, with each step gated by adenosine triphosphate (ATP) binding. Existing models for the gating mechanism propose a role for the microtubule lattice. We show that unpolymerized tubulin binds to kinesin-1, causing tubulin-activated release of adenosine diphosphate (ADP). With no added nucleotide, each kinesin-1 dimer binds one tubulin heterodimer. In adenylyl-imidodiphosphate (AMP-PNP), a nonhydrolyzable ATP analog, each kinesin-1 dimer binds two tubulin heterodimers. The data reveal an ATP gate that operates independently of the microtubule lattice, by ATP-dependent release of a steric or allosteric block on the tubulin binding site of the tethered kinesin-ADP head.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.