ArticleJournal of clinical pathology2007
Upregulation of neutrophil gelatinase-associated lipocalin in oesophageal squamous cell carcinoma: significant correlation with cell differentiation and tumour invasion.
Article in Journal of clinical pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 115 citations in OpenAlex.
- A simple and efficient "cell in situ collagen zymography" technique to evaluate cellular collagenase activities in thyroid cancer cell lines.Molecular biology reports · 2024Article
- The Review of Current Knowledge on Neutrophil Gelatinase-Associated Lipocalin (NGAL).International journal of molecular sciences · 2023Review
- Lipocalin-2 Upregulation in Nasopharyngeal Carcinoma: A Novel Potential Diagnostic Biomarker.Iranian journal of medical sciences · 2023Article
- Sustainable Production of Biosurfactant from Agro-Industrial Oil Wastes byInternational journal of molecular sciences · 2022Article
- Bioinformatic analysis of theFrontiers in cell and developmental biology · 2022Article
- TGF-β-induced PLEK2 promotes metastasis and chemoresistance in oesophageal squamous cell carcinoma by regulating LCN2.Cell death & disease · 2021Article
- Article
- Enzymatic hydrolysis using bacterial cultures as a novel method for obtaining antioxidant peptides from brewers' spent grain.RSC advances · 2021Article
- Elevated plasma level of neutrophil gelatinase-associated lipocalin (NGAL) in patients with breast cancer.International journal of medical sciences · 2021Observational
- Predictive and Prognostic Role of Lipocalin-2 Expression in Prostate Cancer and Its Association with Gleason Score.Prostate cancer · 2021Article
- Review
- Lipocalin-2 expression and function in pancreatic diseases.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2020Review
- Implication and role of neutrophil gelatinase-associated lipocalin in cancer: lipocalin-2 as a potential novel emerging comprehensive therapeutic target for a variety of cancer types.Molecular biology reports · 2020Review
- An Integrative Pan-Cancer Analysis Revealing LCN2 as an Oncogenic Immune Protein in Tumor Microenvironment.Frontiers in oncology · 2020Article
- The role of lipocalin-2 serum levels in the diagnostics of endometrial cancer.Cancer biomarkers : section A of Disease markers · 2019Article
- Effect of Productive Human Papillomavirus 16 Infection on Global Gene Expression in Cervical Epithelium.Journal of virology · 2018Article
- Ell3 stimulates 5-FU resistance in a breast cancer cell line.Oncology letters · 2017Article
- Subcloning and characterization of highly metastatic cells derived from human esophageal squamous cell carcinoma KYSE150 cells by in vivo selection.Oncotarget · 2017Article
- Lipocalin 2 (LCN2) Expression in Hepatic Malfunction and Therapy.Frontiers in physiology · 2016Review
- Lipocalin 2 Enhances Migration and Resistance against Cisplatin in Endometrial Carcinoma Cells.PloS one · 2016Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeutrophil gelatinase-associated lipocalin (NGAL) is a member of the lipocalin family. Recently, an elevated NGAL expression was reported in several types of cancers. However, the characteristics of NGAL expression in oesophageal squamous cell carcinoma (ESCC) are still unknown.
aimTo demonstrate the role of NGAL in ESCC.
methodsNGAL expression in 81 paraffin sections, including ESCC, normal mucosa, simple hyperplasia and dysplasia, and in 73 fresh specimens of ESCC was analysed by immunohistochemistry, western blot and gelatin zymography.
resultsOn immunohistochemical study, ESCC showed a diverse staining pattern for NGAL. However, only a weak positive signal was present within a restricted cytoplasmic area in the normal oesophageal epithelium. In dysplasia, altered NGAL expression could also be observed. On western blot study, NGAL expression level was found to be significantly higher in ESCC than in normal mucosa (p=0.030), and to be positively correlated with cell differentiation. However, no significant association was observed between NGAL expression and cell proliferation. In addition, the enzymic activity of the NGAL/matrix metalloproteinase 9 complex was much higher in ESCC than in normal mucosa, and was significantly correlated with the depth of tumour invasion in zymography analysis (p=0.006).
conclusionsThe findings suggest that NGAL is involved in the differentiation pathway and invasive progression of ESCC.
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