ArticleThe Journal of physiology2007
AMPA receptors associated with zebrafish Mauthner cells switch subunits during development.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Developmental exposure to domoic acid targets reticulospinal neurons and leads to aberrant myelination in the spinal cord.Scientific reports · 2023Article
- Modeling neuromuscular diseases in zebrafish.Frontiers in molecular neuroscience · 2022Review
- Developmental Exposure to Domoic Acid Disrupts Startle Response Behavior and Circuitry in Zebrafish.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Electrical synaptic transmission in developing zebrafish: properties and molecular composition of gap junctions at a central auditory synapse.Journal of neurophysiology · 2014Article
- Maximum likelihood estimation of biophysical parameters of synaptic receptors from macroscopic currents.Frontiers in cellular neuroscience · 2014Article
- Sensory gating of an embryonic zebrafish interneuron during spontaneous motor behaviors.Frontiers in neural circuits · 2014Article
- Patch clamp recordings from embryonic zebrafish Mauthner cells.Journal of visualized experiments : JoVE · 2013Article
- Midline crossing is not required for subsequent pathfinding decisions in commissural neurons.Neural development · 2012Article
- Developmental lead exposure causes startle response deficits in zebrafish.Aquatic toxicology (Amsterdam, Netherlands) · 2011Article
- PKCgamma-induced trafficking of AMPA receptors in embryonic zebrafish depends on NSF and PICK1.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Sequential changes in AMPA receptor targeting in the developing neocortical excitatory circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Zebrafish: An in vivo model for the study of neurological diseases.Neuropsychiatric disease and treatment · 2008Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutamate AMPA receptors (AMPARs) are major excitatory receptors in the vertebrate CNS. In many biological systems there is a developmental speeding in AMPAR kinetics, which occurs either because of a switch in AMPAR subunits or a change in synaptic morphology. We studied the development of AMPAR-mediated miniature excitatory postsynaptic currents (AMPAR-mEPSCs) in zebrafish Mauthner cells (M-cells) to determine the reasons underlying the speeding of AMPA mEPSCs in this preparation. We recorded AMPAR-mEPSCs in zebrafish ranging in age from 33 h postfertilization (hpf) to 72 hpf. We found that the glutamate waveform in the synaptic cleft did not change during development, suggesting that synaptic morphology played little role in shaping the mEPSC. The current-voltage (I-V) relationship was linear at 33 hpf and outwardly rectified in older animals, while AMPAR decay kinetics were slower at positive potentials, compared with negative potentials. The relative change in tau with depolarization was found to be greater at 48 hpf than at 33 hpf. AMPARs in 33 hpf fish had a conductance of approximately 9 pS, and in older fish approximately 15 pS. Finally, the desensitization blocker, cyclothiazide, increased tau by approximately 4-fold in 48 hpf preparations, but only 1.5-fold in 33 hpf fish. These results are consistent with the hypothesis that the major mechanism underlying the developmental speeding in AMPAR kinetics in zebrafish CNS is a switch in receptor subunits. To our knowledge this is the first study to suggest that AMPARs change subunits during development in fish.
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