ArticleNucleic acids research1992
A conserved region in the sea urchin U1 snRNA promoter interacts with a developmentally regulated factor.
Article in Nucleic acids research, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease.Nucleic acids research · 2016Article
- The proximal element is capable of determining proper temporal expression of the embryonic sea urchin U2 snRNA gene.Gene expression · 1994Article
- Formation of the 3' end of sea urchin U1 small nuclear RNA occurs independently of the conserved 3' box and on transcripts initiated from a histone promoter.Molecular and cellular biology · 1992Article
- Two promoter elements are necessary and sufficient for expression of the sea urchin U1 snRNA gene.Nucleic acids research · 1992Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The expression of the sea urchin L. variegatus U1 snRNA gene is temporally regulated during embryogenesis. Using a microinjection assay we show that a region between 203 and 345 nts 5' of the gene is required for expression. There are four conserved regions between two sea urchin species in the 345 nts 5' to the U1 gene. One region, located at about -300, binds a protein factor which is present in blastula but not gastrula nuclei. Three other potential protein binding sites within the first 200 nts 5' to the gene have been identified using a mobility shift assay and/or DNase I footprinting. Two of these regions bind factors which are not developmentally regulated and one binds a factor which is developmentally regulated. It is likely that the factor which binds at -300 is involved in expression and developmental regulation of the sea urchin U1 snRNA gene.
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