ArticleMedical hypotheses2007
Autism, asthma, inflammation, and the hygiene hypothesis.
Article in Medical hypotheses, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01322555 (Neuroimmune Activation in Austism), which is not on this map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neuroimmune Activation in Austism: Imaging Translocator Protein Using Positron Emission Tomography (PET)
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Integrative analysis of genetic data sets reveals a shared innate immune component in autism spectrum disorder and its co-morbidities.Genome biology · 2016Pooled it
- Pooled it
- Cumulative environmental exposures adversely impact social behaviour and are associated with dysregulation of genes and proteins involved in epigenetic, ribosomal, and immune regulation in male mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- The Dangers of Acetaminophen for Neurodevelopment Outweigh Scant Evidence for Long-Term Benefits.Children (Basel, Switzerland) · 2023Review
- Association Between Socioeconomic Status and Prevalence of Hypersensitivity Diseases and Autism: A Nationwide Study of Children.Maternal and child health journal · 2023Article
- Microglia: Synaptic modulator in autism spectrum disorder.Frontiers in psychiatry · 2022Review
- Gut Microbiota Composition and Epigenetic Molecular Changes Connected to the Pathogenesis of Alzheimer's Disease.Journal of molecular neuroscience : MN · 2021Review
- Prevalence of autism spectrum disorders and their relation to selected socio-demographic factors among children aged 18-30 months in northern Vietnam, 2017.International journal of mental health systems · 2019Article
- Gut-Brain Psychology: Rethinking Psychology From the Microbiota-Gut-Brain Axis.Frontiers in integrative neuroscience · 2018Review
- Beyond infection - Maternal immune activation by environmental factors, microglial development, and relevance for autism spectrum disorders.Experimental neurology · 2018Review
- Microglia M2A Polarization as Potential Link between Food Allergy and Autism Spectrum Disorders.Pharmaceuticals (Basel, Switzerland) · 2017Review
- Nematodes and human therapeutic trials for inflammatory disease.Parasite immunology · 2017Review
- The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism.The Journal of international medical research · 2017Review
- Paternal age and psychiatric disorders: A review.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Review
- Developmental neurotoxicity of inhaled ambient ultrafine particle air pollution: Parallels with neuropathological and behavioral features of autism and other neurodevelopmental disorders.Neurotoxicology · 2017Review
- Emerging Roles for the Gut Microbiome in Autism Spectrum Disorder.Biological psychiatry · 2017Review
- From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition.Molecular autism · 2016Review
- Prenatal and Newborn Immunoglobulin Levels from Mother-Child Pairs and Risk of Autism Spectrum Disorders.Frontiers in neuroscience · 2016Article
- Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies.Surgical neurology international · 2015Article
- A model for the induction of autism in the ecosystem of the human body: the anatomy of a modern pandemic?Microbial ecology in health and disease · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Inflammation and the genes, molecules, and biological pathways that lead to inflammatory processes influence many important and disparate biological processes and disease states that are quite often not generally considered classical inflammatory or autoimmune disorders. These include development, reproduction, aging, tumor development and tumor rejection, cardiovascular pathologies, metabolic disorders, as well as neurological and psychiatric disorders. This paper compares parallel aspects of autism and inflammatory disorders with an emphasis on asthma. These comparisons include epidemiological, morphometric, molecular, and genetic aspects of both disease types, contributing to a hypothesis of autism in the context of the immune based hygiene hypothesis. This hypothesis is meant to address the apparent rise in the prevalence of autism in the population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.