Evidence map›Paper›PMID 17411085›Full record

ArticleThe journal of physical chemistry. B2007

Stacking effects on local structure in RNA: changes in the structure of tandem GA pairs when flanking GC pairs are replaced by isoG-isoC pairs.

Gang Chen, Ryszard Kierzek, Ilyas Yildirim, Thomas R Krugh, Douglas H Turner, Scott D Kennedy

Abstract read
In one paragraph

Article in The journal of physical chemistry. B, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Accurate geometrical restraints for Watson-Crick base pairs.Acta crystallographica Section B, Structural science, crystal engineering and materials · 2019
    Article
  3. Review
  4. Physics-based all-atom modeling of RNA energetics and structure.Wiley interdisciplinary reviews. RNA · 2017
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gang ChenDepartment of Chemistry, University of Rochester, Rochester, New York 14627, USA.
Ryszard Kierzek
Ilyas Yildirim
Thomas R Krugh
Douglas H Turner
Scott D Kennedy

Funding

KINETIC AND SPECTROSCOPIC STUDIES OF NUCLEIC ACIDSR01GM022939 · NIGMS · UNIVERSITY OF ROCHESTER · PI TURNER, DOUGLAS H. · 1985 to 2016
$7.6M
FOLDING RNA WITH MODIFIED OLIGONUCLEOTIDESR03TW001068 · FIC · UNIVERSITY OF ROCHESTER · PI TURNER, DOUGLAS H. · 1999 to 2004
$192k
FIC NIH HHS 1R03 TW1068FIC NIH HHS R03 TW001068NIGMS NIH HHS GM22939NIGMS NIH HHS R01 GM022939
6 · The paper itself

Abstract

The Watson-Crick-like isoG-isoC (iGiC) pair, with the amino and carbonyl groups transposed relative to the Watson-Crick GC pair, provides an expanded alphabet for understanding interactions that shape nucleic acid structure. Here, thermodynamic stabilities of tandem GA pairs flanked by iGiC pairs are reported along with the NMR structures of the RNA self-complementary duplexes (GCiGGAiCGCA)2 and (GGiCGAiGCCA)2. A sheared GA pairing forms in (GCiGGAiCGCA)2, and an imino GA pairing forms in (GGiCGAiGCCA)2. The structures contrast with the formation of tandem imino and sheared GA pairs flanked by GC pairs in the RNA self-complementary duplexes (GCGGACGC)2 and (GGCGAGCC)2, respectively. In both iGiC duplexes, Watson-Crick-like hydrogen bonds are formed between iG and iC, and iGiC substitutions result in less favorable loop stability. The results provide benchmarks for testing computations of molecular interactions that shape RNA three-dimensional structure.

Indexed as

Base PairingNucleic Acid ConformationAdenineCytidineGuanineHydrogen BondingModels, MolecularNuclear Magnetic Resonance, BiomolecularRNAThermodynamicsAdenineCytidineGuanineisocytidineisoguanineRNA

Identifiers

PMID17411085
PMCPMC3738747

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.