Evidence map›Paper›PMID 17410480›Full record

ReviewMycopathologia2007

Update on the contribution of galactomannan for the diagnosis of invasive aspergillosis.

Valério R Aquino, Luciano Z Goldani, Alesssandro C Pasqualotto

Abstract readReview
PubMed Publisher
In one paragraph

Review in Mycopathologia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 74 citations in OpenAlex.

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  15. PCR-based diagnosis of human fungal infections.Expert review of anti-infective therapy · 2009
    Review
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  17. Diagnosis of invasive aspergillosis using bronchoalveolar lavage in haematology patients: influence of bronchoalveolar lavage human DNA content on real-time PCR performance.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2009
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Valério R AquinoMycology Laboratory, Service of Clinical Pathology, Hospital de Clínicas de Porto Alegre, Rio Grande do Sul, Brazil.
Luciano Z Goldani
Alesssandro C Pasqualotto
Hospital de Clínicas de Porto Alegre · BRUniversidade Federal do Rio Grande do Sul · BRUniversity of Manchester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The diagnosis of invasive fungal infections (IFI) remains a challenge, particularly for diseases caused by filamentous fungi such as Aspergillus species. Unfortunately, many patients affected by these conditions are not identified before autopsy. Therefore, there is a need for new diagnostic methods for IFI. Galactomannan is a soluble antigen released during hyphal growth in tissues. A commercially available sandwich ELISA assay that detects galactomannan has been used in Europe for many years and is now approved for use in the USA. The test has an excellent negative predictive value in the detection of invasive aspergillosis (IA) in high-risk patients. In addition, it is more sensitive than culture and allows IA to be diagnosed before clinical manifestations occur. However, false-negative and false-positive results in certain populations are the main limitations to its use. The purpose of this review is to summarize the current knowledge about galactomannan testing in patients at risk for IA.

Indexed as

AnimalsAspergillosisBiomarkersEnzyme-Linked Immunosorbent AssayFalse Negative ReactionsFalse Positive ReactionsGalactoseHematopoietic Stem Cell TransplantationHumansMannansMiceOrgan TransplantationRabbitsSensitivity and SpecificityBiomarkersgalactomannanGalactoseMannans

Identifiers

PMID17410480
OpenAlexW1988473317

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.