ArticleJournal of neural engineering2007
Trophic factor induction of human umbilical cord blood cells in vitro and in vivo.
Article in Journal of neural engineering, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Gold Nanostrip Array-Mediated Wireless Electrical Stimulation for Accelerating Functional Neuronal Differentiation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Injectable biomaterial shuttles for cell therapy in stroke.Brain research bulletin · 2021Review
- Human Induced Pluripotent Stem Cells : Clinical Significance and Applications in Neurologic Diseases.Journal of Korean Neurosurgical Society · 2019Article
- Estrogen Secreted by Mesenchymal Stem Cells Necessarily Determines Their Feasibility of Therapeutical Application.Scientific reports · 2015Article
- Immunohistochemical toolkit for tracking and quantifying xenotransplanted human stem cells.Regenerative medicine · 2014Article
- Progress in stem cell therapy for major human neurological disorders.Stem cell reviews and reports · 2013Review
- Repairing neural injuries using human umbilical cord blood.Molecular neurobiology · 2013Review
- Trophic factors and cell therapy to stimulate brain repair after ischaemic stroke.Journal of cellular and molecular medicine · 2012Review
- Effects of intravenous administration of human umbilical cord blood stem cells in 3-acetylpyridine-lesioned rats.Stem cells international · 2012Article
- BAD phosphorylation determines ovarian cancer chemosensitivity and patient survival.Clinical cancer research : an official journal of the American Association for Cancer Research · 2011Article
- Transplantation of umbilical cord blood stem cells for treating spinal cord injury.Stem cell reviews and reports · 2011Review
- Human Umbilical Cord Blood Cells Have Trophic Effects on Young and Aging Hippocampal Neurons in Vitro.Aging and disease · 2010Article
- Long-term cultured human umbilical cord neural-like cells transplanted into the striatum of NOD SCID mice.Brain research bulletin · 2007Article
- Umbilical cord blood research: current and future perspectives.Cell transplantation · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
The mononuclear fraction of human umbilical cord blood (HUCBmnf) is a mixed cell population that multiple research groups have shown contains cells that can express neural proteins. In these studies, we have examined the ability of the HUCBmnf to express neural antigens after in vitro exposure to defined media supplemented with a cocktail of growth and neurotrophic factors. It is our hypothesis that by treating the HUCBmnf with these developmentally-relevant factors, we can expand the population, enhance the expression of neural antigens and increase cell survival upon transplantation. Prior to growth factor treatment in culture, expression of stem cell antigens is greater in the non-adherent HUCBmnf cells compared to the adherent cells (p < 0.05). Furthermore, treatment of the non-adherent cells with growth factors, increases BrdU incorporation, especially after 14 days in vitro (DIV). In HUCBmnf-embryonic mouse striata co-culture, a small number of growth factor treated HUCBmnf cells were able to integrate into the growing neural network and express immature (nestin and TuJ1) and mature (GFAP and MAP2) neural markers. Treated HUCBmnf cells implanted in the subventricular zone predominantly expressed GFAP although some grafted HUCBmnf cells were MAP2 positive. While short-term treatment of HUCBmnf cells with growth and neurotrophic factors enhanced proliferative capacity in vitro and survival of the cells in vivo, the treatment regimen employed was not enough to ensure long-term survival of HUCBmnf-derived neurons necessary for cell replacement therapies for neurodegenerative diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.