ArticleMolecular biology of the cell2007
Mitotic chromosome biorientation in fission yeast is enhanced by dynein and a minus-end-directed, kinesin-like protein.
Article in Molecular biology of the cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Force by minus-end motors Dhc1 and Klp2 collapses the S. pombe spindle after laser ablation.Biophysical journal · 2022Article
- Kinesin-14 family proteins and microtubule dynamics defineJournal of cell science · 2020Article
- Electron tomography reveals aspects of spindle structure important for mechanical stability at metaphase.Molecular biology of the cell · 2020Article
- Mad1 promotes chromosome congression by anchoring a kinesin motor to the kinetochore.Nature cell biology · 2015Article
- Loss of kinesin-14 results in aneuploidy via kinesin-5-dependent microtubule protrusions leading to chromosome cut.Nature communications · 2015Article
- The Msd1-Wdr8-Pkl1 complex anchors microtubule minus ends to fission yeast spindle pole bodies.The Journal of cell biology · 2015Article
- Kinesin-14 and kinesin-5 antagonistically regulate microtubule nucleation by γ-TuRC in yeast and human cells.Nature communications · 2014Article
- Antagonistic spindle motors and MAPs regulate metaphase spindle length and chromosome segregation.Current biology : CB · 2013Article
- Microtubules and Alp7-Alp14 (TACC-TOG) reposition chromosomes before meiotic segregation.Nature cell biology · 2013Article
- Conserved and divergent features of kinetochores and spindle microtubule ends from five species.The Journal of cell biology · 2013Article
- Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Csi1 links centromeres to the nuclear envelope for centromere clustering.The Journal of cell biology · 2012Article
- Mitosis futures: the past is prologue.Molecular biology of the cell · 2011Article
- Tubulin depolymerization may be an ancient biological motor.Journal of cell science · 2010Review
- Tip1/CLIP-170 protein is required for correct chromosome poleward movement in fission yeast.PloS one · 2010Article
- Mechanisms of chromosome behaviour during mitosis.Nature reviews. Molecular cell biology · 2010Review
- Bub3p facilitates spindle checkpoint silencing in fission yeast.Molecular biology of the cell · 2009Article
- Bub1 and Bub3 promote the conversion from monopolar to bipolar chromosome attachment independently of shugoshin.EMBO reports · 2009Article
- Diffusion and directed movement: in vitro motile properties of fission yeast kinesin-14 Pkl1.The Journal of biological chemistry · 2008Article
- Ncd motor binding and transport in the spindle.Journal of cell science · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Chromosome biorientation, the attachment of sister kinetochores to sister spindle poles, is vitally important for accurate chromosome segregation. We have studied this process by following the congression of pole-proximal kinetochores and their subsequent anaphase segregation in fission yeast cells that carry deletions in any or all of this organism's minus end-directed, microtubule-dependent motors: two related kinesin 14s (Pkl1p and Klp2p) and dynein. None of these deletions abolished biorientation, but fewer chromosomes segregated normally without Pkl1p, and to a lesser degree without dynein, than in wild-type cells. In the absence of Pkl1p, which normally localizes to the spindle and its poles, the checkpoint that monitors chromosome biorientation was defective, leading to frequent precocious anaphase. Ultrastructural analysis of mutant mitotic spindles suggests that Pkl1p contributes to error-free biorientation by promoting normal spindle pole organization, whereas dynein helps to anchor a focused bundle of spindle microtubules at the pole.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.