ArticleAmerican journal of physiology. Renal physiology2007
Crucial role of Rho-nuclear factor-kappaB axis in angiotensin II-induced renal injury.
Article in American journal of physiology. Renal physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 40 citations in OpenAlex.
- Correlation analysis of cofilin-1 with renal prognosis in primary IgA nephropathy.BMC nephrology · 2024Article
- The Urinary Angiotensinogen to Urinary Albumin Ratio Reflects Whether the Renin-angiotensin System in the Kidney Is Activated due to Filtration of Plasma Angiotensinogen through the Damaged Glomeruli or the Production of Angiotensinogen in the Proximal Tubules.Internal medicine (Tokyo, Japan) · 2020Article
- Classic and Nonclassic Renin-Angiotensin Systems in the Critically Ill.Critical care clinics · 2019Review
- Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology.Physiological reviews · 2018Review
- BCL6 attenuates renal inflammation via negative regulation of NLRP3 transcription.Cell death & disease · 2017Article
- Increased angiotensinogen expression, urinary angiotensinogen excretion, and tissue injury in nonclipped kidneys of two-kidney, one-clip hypertensive rats.American journal of physiology. Renal physiology · 2016Article
- Resveratrol ameliorates renal injury in spontaneously hypertensive rats by inhibiting renal micro-inflammation.Bioscience reports · 2016Article
- Cofilin1 is involved in hypertension-induced renal damage via the regulation of NF-κB in renal tubular epithelial cells.Journal of translational medicine · 2015Article
- Renoprotective effects of direct renin inhibition in glomerulonephritis.The American journal of the medical sciences · 2014Article
- Cardiac-specific suppression of NF-κB signaling prevents diabetic cardiomyopathy via inhibition of the renin-angiotensin system.American journal of physiology. Heart and circulatory physiology · 2014Article
- ROCK/NF-κB axis-dependent augmentation of angiotensinogen by angiotensin II in primary-cultured preglomerular vascular smooth muscle cells.American journal of physiology. Renal physiology · 2014Article
- Association of elevated urinary concentration of renin-angiotensin system components and severe AKI.Clinical journal of the American Society of Nephrology : CJASN · 2013Article
- Role of mineralocorticoid receptor/Rho/Rho-kinase pathway in obesity-related renal injury.International journal of obesity (2005) · 2012Article
- Evidence for a functional intracellular angiotensin system in the proximal tubule of the kidney.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Review
- The establishment of a primary culture system of proximal tubule segments using specific markers from normal mouse kidneys.International journal of molecular sciences · 2012Article
- Urinary angiotensinogen as a novel early biomarker of intrarenal renin-angiotensin system activation in experimental type 1 diabetes.Journal of pharmacological sciences · 2012Article
- Rho-kinase/nuclear factor-κβ/angiotensinogen axis in angiotensin II-induced renal injury.Hypertension research : official journal of the Japanese Society of Hypertension · 2011Article
- Androgen-dependent hypertension is mediated by 20-hydroxy-5,8,11,14-eicosatetraenoic acid-induced vascular dysfunction: role of inhibitor of kappaB Kinase.Hypertension (Dallas, Tex. : 1979) · 2011Article
- Contribution of a nuclear factor-kappaB binding site to human angiotensinogen promoter activity in renal proximal tubular cells.Hypertension (Dallas, Tex. : 1979) · 2011Article
- Effects of systemic inhibition of Rho kinase on blood pressure and renal haemodynamics in diabetic rats.British journal of pharmacology · 2011Article
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2 authors at 1 institution in 1 country.
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Abstract
This study was performed to determine the effectiveness of the Rho kinase inhibitor and NF-kappaB inhibitor in renal injury of ANG II-infused hypertensive rats. Male Sprague-Dawley rats, maintained on a normal diet, received either a sham operation (n = 7) or continuous ANG II infusion (120 ng/min) subcutaneously via minipumps. The ANG II-infused rats were further subdivided into three subgroups (n = 7 each) to receive one of the following treatments during the entire period: vehicle, Rho kinase inhibitor (fasudil; 3 mg.kg(-1).day(-1) ip), or NF-kappaB inhibitor (parthenolide; 1 mg.kg(-1).day(-1) ip). After 12 days of ANG II infusion, systolic blood pressure (BP; 208 +/- 7 vs. 136 +/- 3 mmHg), Rho kinase activity, NF-kappaB activity, renal ANG II contents (160 +/- 25 vs. 84 +/- 14 pg/g), monocytic chemotactic protein (MCP) 1 mRNA, interstitial macrophage infiltration, transforming growth factor-beta1 (TGF-beta1) mRNA, interstitial collagen-positive area, urinary protein excretion (43 +/- 6 vs. 11 +/- 2 mg/day), and urinary albumin excretion were significantly enhanced compared with the Sham group. While fasudil or parthenolide did not alter systolic BP (222 +/- and 190 +/- 21, respectively), both treatments completely blocked ANG II-induced enhancement of NF-kappaB activity, renal ANG II contents (103 +/- 11 and 116 +/- 21 pg/g, respectively), MCP1 mRNA, interstitial macrophage infiltration, TGF-beta1 mRNA, interstitial collagen-positive area, urinary protein excretion (28 +/- 6 and 23 +/- 3 mg/day, respectively), and urinary albumin excretion. Importantly, parthenolide did not alter ANG II-induced Rho kinase activation although fasudil abolished ANG II-induced Rho kinase activation. These data indicate that the Rho-NF-kappaB axis plays crucial roles in the development of ANG II-induced renal injury independently from BP regulation.
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