ArticleJournal of virology2007
MEK1/2 inhibitors block basal and transforming growth factor 1beta1-stimulated JC virus multiplication.
Article in Journal of virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- The oncogenic roles of JC polyomavirus in cancer.Frontiers in oncology · 2022Review
- Article
- JCPyV-Induced MAPK Signaling Activates Transcription Factors during Infection.International journal of molecular sciences · 2019Article
- Human DNA Virus Exploitation of the MAPK-ERK Cascade.International journal of molecular sciences · 2019Review
- High-Throughput Characterization of Viral and Cellular Protein Expression Patterns During JC Polyomavirus Infection.Frontiers in microbiology · 2019Article
- Role of MAPK/MNK1 signaling in virus replication.Virus research · 2018Review
- ERK Is a Critical Regulator of JC Polyomavirus Infection.Journal of virology · 2018Article
- Hepatitis C virus infection stimulates transforming growth factor-β1 expression through up-regulating miR-192.Journal of microbiology (Seoul, Korea) · 2016Article
- Differentiation of human fetal multipotential neural progenitor cells to astrocytes reveals susceptibility factors for JC virus.Journal of virology · 2013Article
- Article
- Hepatitis C virus-induced furin and thrombospondin-1 activate TGF-β1: role of TGF-β1 in HCV replication.Virology · 2011Article
- Article
- Glial cell type-specific subcellular localization of 14-3-3 zeta: an implication for JCV tropism.Glia · 2009Article
- Reovirus activates transforming growth factor beta and bone morphogenetic protein signaling pathways in the central nervous system that contribute to neuronal survival following infection.Journal of virology · 2009Article
- Article
- DNA-binding transcription factor NF-1A negatively regulates JC virus multiplication.The Journal of general virology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The multiplication of the human neurotropic polyomavirus JC virus (JCV) is regulated by cell membrane receptors and nuclear transcription factors. Signaling pathways also play a role in determining the extent to which JCV can productively infect cells. These data show that constitutively active MEK1 protein (CA-MEK1), overexpressed in cultures of human glia, supports a substantial increase in late JCV protein (Vp-1) synthesis. The specificity of this pathway was indicated by no significant enhancement of JCV multiplication through activation of other components of mitogen-activated protein kinase pathways such as p38, Jun N-terminal protein kinase, and protein kinase A. Further evidence supporting the importance of signaling in JCV infection came from addition of transforming growth factor beta1 (TGF-beta1), which stimulated a 200% increase of Vp-1 expression. Specific MEK1/2 inhibitors, flavenoid PD98059 and U0126, decreased the basal and TGF-beta1-stimulated Vp-1 expression by 95% or more. TGF-beta1 is known to phosphorylate/activate Smad DNA binding proteins that could subsequently bind or increase binding to JCV promoter sequences, linking the effects of signaling with JCV transcriptional regulation. The effectiveness with which MEK1/2 inhibitors block JCV multiplication provides insight that may contribute to development of compounds directed against JCV.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.