ArticleGut2007
Experimental acute pancreatitis in PAP/HIP knock-out mice.
Article in Gut, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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Who cites it
38 citing papers in PubMed, 84 citations in OpenAlex.
- STATs Signaling Pathways in Acute Pancreatitis: Mechanisms and Regulation.International journal of medical sciences · 2026Review
- Reg3γ: current understanding and future therapeutic opportunities in metabolic disease.Experimental & molecular medicine · 2023Review
- Reg family proteins contribute to inflammation and pancreatic stellate cells activation in chronic pancreatitis.Scientific reports · 2023Article
- Interdependencies of Gene Expression and Function between Two Redox Enzymes and REG Family Proteins in Murine Pancreatic Islets and Human Pancreatic Cells.Antioxidants (Basel, Switzerland) · 2023Article
- Antimicrobial protein REG3A regulates glucose homeostasis and insulin resistance in obese diabetic mice.Communications biology · 2023Article
- MyD88 deficiency aggravates the severity of acute pancreatitis by promoting MyD88-independent TRIF pathway-mediated necrosis.Annals of translational medicine · 2022Article
- Regenerating islet-derived protein 3α: A promising therapy for diabetes. Preliminary data in rodents and in humans.Heliyon · 2022Article
- Endoplasmic reticulum stress promoted acinar cell necroptosis in acute pancreatitis through cathepsinB-mediated AP-1 activation.Frontiers in immunology · 2022Article
- Effects of Intermittent Hypoxia on Cytokine Expression Involved in Insulin Resistance.International journal of molecular sciences · 2021Review
- Exosomes Secreted by Umbilical Cord Blood-Derived Mesenchymal Stem Cell Attenuate Diabetes in Mice.Journal of diabetes research · 2021Article
- Myeloid-specific dopamine DBritish journal of pharmacology · 2020Article
- Role of regenerating islet-derived proteins in inflammatory bowel disease.World journal of gastroenterology · 2020Review
- HIP/PAP protects against bleomycin-induced lung injury and inflammation and subsequent fibrosis in mice.Journal of cellular and molecular medicine · 2020Article
- Hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP) confers protection against hepatic fibrosis through downregulation of transforming growth factor β receptor II.Laboratory investigation; a journal of technical methods and pathology · 2020Article
- Reg3 Proteins as Gut Hormones?Endocrinology · 2019Review
- Role of Regenerating Islet-Derived Protein 3A in Gastrointestinal Cancer.Frontiers in oncology · 2019Review
- Up-regulation ofBiochemistry and biophysics reports · 2017Article
- Deletion Of XIAP reduces the severity of acute pancreatitis via regulation of cell death and nuclear factor-κB activity.Cell death & disease · 2017Article
- Deteriorated high-fat diet-induced diabetes caused by pancreatic β-cell-specific overexpression of Reg3β gene in mice.Endocrine · 2016Article
- Mechanisms of interleukin-22's beneficial effects in acute pancreatitis.World journal of gastrointestinal pathophysiology · 2016Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
BACKGROUND AND
aimsPAP/HIP was first reported as an additional pancreatic secretory protein expressed during the acute phase of pancreatitis. It was shown in vitro to be anti-apoptotic and anti-inflammatory. This study aims to look at whether PAP/HIP plays the same role in vivo.
methodsA model of caerulein-induced pancreatitis was used to compare the outcome of pancreatitis in PAP/HIP(-/-) and wild-type mice.
resultsPAP/HIP(-/-) mice showed the normal phenotype at birth and normal postnatal development. Caerulein-induced pancreatic necrosis was, however, less severe in PAP/HIP(-/-) mice than in wild-type mice, as judged by lower amylasemia and lipasemia levels and smaller areas of necrosis. On the contrary, pancreas from PAP/HIP(-/-) mice was more sensitive to apoptosis, in agreement with the anti-apoptotic effect of PAP/HIP in vitro. Surprisingly, pancreatic inflammation was more extensive in PAP/HIP(-/-) mice, as judged from histological parameters, increased myeloperoxidase activity and increased pro-inflammatory cytokine expression. This result, in apparent contradiction with the limited necrosis observed in these mice, is, however, in agreement with the anti-inflammatory function previously reported in vitro for PAP/HIP. This is supported by the observation that activation of the STAT3/SOCS3 pathway was strongly decreased in the pancreas of PAP/HIP(-/-) mice and by the reversion of the apoptotic and inflammatory phenotypes upon administration of recombinant PAP/HIP to PAP/HIP(-/-) mice.
conclusionThe anti-apoptotic and anti-inflammatory functions described in vitro for PAP/HIP have physiological relevance in the pancreas in vivo during caerulein-induced pancreatitis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.