ArticleGenetics2007
Stepping-stone spatial structure causes slow decay of linkage disequilibrium and shifts the site frequency spectrum.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Article
- Study design and the sampling of deleterious rare variants in biobank-scale datasets.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Evolutionary Genomics of Sister Species Differing in Effective Population Sizes and Recombination Rates.Genome biology and evolution · 2023Article
- Demographic modeling of admixed Latin American populations from whole genomes.American journal of human genetics · 2023Article
- The design of mapping populations: Impacts of geographic scale on genetic architecture and mapping efficacy for defense and immunity.Current opinion in plant biology · 2023Review
- The Linkage-Disequilibrium and Recombinational Landscape in Daphnia pulex.Genome biology and evolution · 2022Article
- Evolutionary Genomics of a Subdivided Species.Molecular biology and evolution · 2022Article
- Detecting Positive Selection in Populations Using Genetic Data.Methods in molecular biology (Clifton, N.J.) · 2020Article
- A survey of methods and tools to detect recent and strong positive selection.Journal of biological research (Thessalonike, Greece) · 2017Review
- Distinguishing recent admixture from ancestral population structure.Genome biology and evolution · 2017Article
- Pleistocene sea level fluctuation and host plant habitat requirement influenced the historical phylogeography of the invasive species Amphiareus obscuriceps (Hemiptera: Anthocoridae) in its native range.BMC evolutionary biology · 2016Article
- Isolation-by-distance-and-time in a stepping-stone model.Theoretical population biology · 2016Article
- Genomic signatures of population decline in the malaria mosquito Anopheles gambiae.Malaria journal · 2016Article
- A Spatial Framework for Understanding Population Structure and Admixture.PLoS genetics · 2016Article
- Phylogeographic structure of cotton pest Adelphocoris suturalis (Hemiptera: Miridae): strong subdivision in China inferred from mtDNA and rDNA ITS markers.Scientific reports · 2015Article
- Investigating sex-specific dynamics using uniparental markers: West New Guinea as a case study.Ecology and evolution · 2013Article
- Inferring population size changes with sequence and SNP data: lessons from human bottlenecks.Heredity · 2013Review
- Phylogeographic patterns of mtDNA variation revealed multiple glacial refugia for the frog species Feirana taihangnica endemic to the Qinling Mountains.Journal of molecular evolution · 2013Article
- Complex patterns of local adaptation in teosinte.Genome biology and evolution · 2013Article
- Small effective population size and genetic homogeneity in the Val Borbera isolate.European journal of human genetics : EJHG · 2013Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The symmetric island model with D demes and equal migration rates is often chosen for the investigation of the consequences of population subdivision. Here we show that a stepping-stone model has a more pronounced effect on the genealogy of a sample. For samples from a small geographical region commonly used in genetic studies of humans and Drosophila, there is a shift of the frequency spectrum that decreases the number of low-frequency-derived alleles and skews the distribution of statistics of Tajima, Fu and Li, and Fay and Wu. Stepping-stone spatial structure also changes the two-locus sampling distribution and increases both linkage disequilibrium and the probability that two sites are perfectly correlated. This may cause a false prediction of cold spots of recombination and may confuse haplotype tests that compute probabilities on the basis of a homogeneously mixing population.
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