Evidence map›Paper›PMID 17408842›Full record

ReviewBiochimie

Post-transcriptional control of the interferon system.

Khalid S A Khabar, Howard A Young

Open access · greenAbstract readReview
In one paragraph

Review in Biochimie. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 85 citations in OpenAlex.

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  12. Immune Response in Young Thoroughbred Racehorses under Training.Animals : an open access journal from MDPI · 2020
    Article
  13. Novel In Situ Hybridization and Multiplex Immunofluorescence Technology Combined With Whole-slide Digital Image Analysis in Kidney Transplantation.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2020
    Article
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Khalid S A KhabarProgram in BioMolecular Research, King Faisal Specialist Hospital and Research Center, P3354, MBC-03, Takhasusi Road, Riyadh 11211, Saudi Arabia. khabar@kfshrc.edu.sa
Howard A Young
King Faisal Specialist Hospital & Research Centre · SANational Cancer Institute · US

Funding

CONTROL OF HUMAN INTERFERON GAMMA GENE EXPRESSIONZ01BC009283 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI YOUNG, HOWARD A · 1996 to 2008
$2.6M
Intramural NIH HHS Z01 BC009283
6 · The paper itself

Abstract

The interferon (IFN) system is a well-controlled network of signaling, transcriptional, and post-transcriptional processes that orchestrate host defense against microbes. The IFN response comprises a multi-array of IFN-stimulated gene products that mediate a variety of biological processes designed to control infection and regulate specific immune responses. In this review, we focus on post-transcriptional mechanisms of gene regulation that occur during the course of IFN induction and during the response of cells to IFN. Post-transcriptional mechanisms involve different levels of regulation such as mRNA stability, alternative splicing, and translation. Such controls offer a fine tuning mechanism for efficient and rapid response and as a negative feedback control in IFN biosynthesis and response.

Indexed as

RNA Processing, Post-Transcriptional3' Untranslated RegionsAnimalsBase SequenceeIF-2 KinaseEndoribonucleasesFeedback, PhysiologicalHumansInterferon-betaInterferon-gammaInterferonsModels, BiologicalMolecular Sequence DataSignal TransductionTranscription, Genetic2-5A-dependent ribonuclease3' Untranslated RegionseIF-2 KinaseEndoribonucleasesInterferon-betaInterferon-gammaInterferons

Identifiers

PMID17408842
PMCPMC1994070
OpenAlexW1999206942

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.