ArticleBMC systems biology2007
Dynamics of in silico leukocyte rolling, activation, and adhesion.
Article in BMC systems biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 54 citations in OpenAlex.
- Integrative lymph node-mimicking models created with biomaterials and computational tools to study the immune system.Materials today. Bio · 2022Review
- Expected impact of lockdown measures due to COVID-19 on disabling conditions: a modelling study of chronic low back pain.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2021Article
- Agent-Based Modeling of Systemic Inflammation: A Pathway Toward Controlling Sepsis.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Agent-based model illustrates the role of the microenvironment in regeneration in healthy and mdx skeletal muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Agent-based modeling of the interaction between CD8+ T cells and Beta cells in type 1 diabetes.PloS one · 2018Article
- Introduction of a Framework for Dynamic Knowledge Representation of the Control Structure of Transplant Immunology: Employing the Power of Abstraction with a Solid Organ Transplant Agent-Based Model.Frontiers in immunology · 2015Article
- Agent-based model of fecal microbial transplant effect on bile acid metabolism on suppressing Clostridium difficile infection: an example of agent-based modeling of intestinal bacterial infection.Journal of pharmacokinetics and pharmacodynamics · 2014Article
- Hybrid equation/agent-based model of ischemia-induced hyperemia and pressure ulcer formation predicts greater propensity to ulcerate in subjects with spinal cord injury.PLoS computational biology · 2013Article
- Phenotypic transition maps of 3D breast acini obtained by imaging-guided agent-based modeling.Integrative biology : quantitative biosciences from nano to macro · 2011Article
- Identifying the rules of engagement enabling leukocyte rolling, activation, and adhesion.PLoS computational biology · 2010Article
- At the biological modeling and simulation frontier.Pharmaceutical research · 2009Review
- Computational investigation of epithelial cell dynamic phenotype in vitro.Theoretical biology & medical modelling · 2009Article
- Agent-based model of therapeutic adipose-derived stromal cell trafficking during ischemia predicts ability to roll on P-selectin.PLoS computational biology · 2009Article
- Elongation, proliferation & migration differentiate endothelial cell phenotypes and determine capillary sprouting.BMC systems biology · 2009Article
- Altered P-selectin and CD44 expression in the renal tissues and peripheral blood of children with IgA nephropathy.International urology and nephrology · 2009Article
- Article
- Essential operating principles for tumor spheroid growth.BMC systems biology · 2008Article
- A hybrid computational model for phagocyte transmigration.Proceedings. IEEE International Symposium on Bioinformatics and Bioengineering · 2008Article
- A framework and mechanistically focused, in silico method for enabling rational translational research.Summit on translational bioinformatics · 2008Article
- An in silico transwell device for the study of drug transport and drug-drug interactions.Pharmaceutical research · 2007Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe present a multilevel, agent based, in silico model that represents the dynamics of rolling, activation, and adhesion of individual leukocytes in vitro. Object-oriented software components were designed, verified, plugged together, and then operated in ways that represent the molecular and cellular mechanisms believed responsible for leukocyte rolling and adhesion. The result is an in silico analogue of an experimental in vitro system. The experimentally measured, phenotypic attributes of the analogue were compared and contrasted to those of leukocytes in vitro from three different experimental conditions.
resultsThe individual in silico dynamics of "rolling" on simulated P-selectin, and separately on simulated VCAM-1, were an acceptable match to individual in vitro distance-time and velocity-time measurements. The analogues are also able to represent the transition from rolling to adhesion on P-selectin and VCAM-1 in the presence of GRO-alpha chemokine. The individual in silico and in vitro behavioral similarities translated successfully to population level measures. These behavioral similarities were enabled in part by subdividing the functionality of the analogue's surface into 600 independent, "cell"-controlled, equally capable modules of comparable functionality.
conclusionThe overlap in phenotypic attributes of our analogue with those of leukocytes in vitro confirm the considerable potential of our model for studying the key events that determine the behavioral outcome of individual leukocytes during rolling, activation, and adhesion. Our results provide an important foundation and framework for future in silico research into plausible causal links between well-documented, subcellular molecular level events and the variety of systemic phenotypic attributes that distinguish normal leukocyte adhesion from abnormal disease-associated adhesion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.