ReviewExpert review of vaccines2007
Clinical utilization of chemokines to combat cancer: the double-edged sword.
Review in Expert review of vaccines, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Aberrant regulation of CXCR4 in cancer via deviant microRNA-targeted interactions.Epigenetics · 2022Review
- Camptothecin Induces PD-L1 and Immunomodulatory Cytokines in Colon Cancer Cells.Medicines (Basel, Switzerland) · 2019Article
- Circulating inflammatory markers and colorectal cancer risk: A prospective case-cohort study in Japan.International journal of cancer · 2018Article
- Salivary cytokine panel indicative of non-small cell lung cancer.The Journal of international medical research · 2018Article
- Methods for improving the immunogenicity and efficacy of cancer vaccines.Expert opinion on biological therapy · 2018Review
- Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation.Science signaling · 2017Article
- Granulocytic immune infiltrates are essential for the efficient formation of breast cancer liver metastases.Breast cancer research : BCR · 2015Article
- Specific medicinal plant polysaccharides effectively enhance the potency of a DC-based vaccine against mouse mammary tumor metastasis.PloS one · 2015Article
- Chemokines as Cancer Vaccine Adjuvants.Vaccines · 2013Article
- CXCR4 negatively regulates keratinocyte proliferation in IL-23-mediated psoriasiform dermatitis.The Journal of investigative dermatology · 2013Article
- CCL19 as an adjuvant for intradermal gene gun immunization in a Her2/neu mouse tumor model: improved vaccine efficacy and a role for B cells as APC.Cancer gene therapy · 2012Article
- A locked, dimeric CXCL12 variant effectively inhibits pulmonary metastasis of CXCR4-expressing melanoma cells due to enhanced serum stability.Molecular cancer therapeutics · 2012Article
- CCL21 (SLC) improves tumor protection by a DNA vaccine in a Her2/neu mouse tumor model.Cancer gene therapy · 2012Article
- Fragment-based optimization of small molecule CXCL12 inhibitors for antagonizing the CXCL12/CXCR4 interaction.Current topics in medicinal chemistry · 2012Article
- Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- DNA vaccines: developing new strategies against cancer.Journal of biomedicine & biotechnology · 2010Review
- Lung and splenic B cells facilitate diverse effects on in vitro measures of antitumor immune responses.Cancer immunity · 2008Article
- DNA vaccines: precision tools for activating effective immunity against cancer.Nature reviews. Cancer · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Chemokines are a small group of related chemo-attractant peptides that play an essential role in the homeostatic maintenance of the immune system. They control the recruitment of cells needed for the induction and activation of innate and adaptive immune responses. However, tumors also utilize chemokines to actively progress and evade immunosurveillance. In fact, chemokines are involved directly or indirectly in almost every aspect of tumorigenesis. They mediate survival and metastatic spread of tumors, promote new blood vessel formation (neovascularization) and induce an immunosuppressive microenvironment via recruitment of immunosuppressive cells. As a result, a number of therapeutic strategies have been proposed to target almost every step of the chemokine/chemokine receptor involvement in tumors. Yet, despite occasional success stories, most of them appear to be ineffective or impractical, presumably due to 'nonspecific' harm of cells needed for the elimination of tumor escapees and maintenance of immunological memory. The strategy would only be effective if it also promoted antitumor adaptive immune responses capable of combating a residual disease and tumor relapse.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.