ArticlePLoS biology2007
Survey sequencing and comparative analysis of the elephant shark (Callorhinchus milii) genome.
Article in PLoS biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 148 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
148 citing papers in PubMed, 313 citations in OpenAlex.
- Genome-wide identification and solute selectivity of aquaporins in the sharpnose sevengill shark, Heptranchias perlo.Physiological reports · 2026Article
- Silver chimaera genome highlights lineage-specific sex chromosome and opsin gene evolution in holocephalans.DNA research : an international journal for rapid publication of reports on genes and genomes · 2026Article
- Origin of immunoglobulins and T cell receptors: A candidate gene for invasion by the RAG transposon.Science advances · 2025Article
- Whole-Genome Sequencing ofAnimals : an open access journal from MDPI · 2025Article
- The Sensory Shark: High-quality Morphological, Genomic and Transcriptomic Data for the Small-spotted Catshark Scyliorhinus Canicula Reveal the Molecular Bases of Sensory Organ Evolution in Jawed Vertebrates.Molecular biology and evolution · 2024Article
- The Evolution and Role of Molecular Tools in Measuring Diversity and Genomic Selection in Livestock Populations (Traditional and Up-to-Date Insights): A Comprehensive Exploration.Veterinary sciences · 2024Review
- Article
- Three amphioxus reference genomes reveal gene and chromosome evolution of chordates.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Complete mitochondrial genome ofMitochondrial DNA. Part B, Resources · 2023Article
- Teleostean fishes may have developed an efficient NaFrontiers in physiology · 2022Article
- Comprehensive Draft Genome Analyses of Three Rockfishes (Scorpaeniformes,Current issues in molecular biology · 2021Article
- Analysis of shark NCR3 family genes reveals primordial features of vertebrate NKp30.Immunogenetics · 2021Article
- The gastrin-releasing peptide/bombesin system revisited by a reverse-evolutionary study considering Xenopus.Scientific reports · 2021Article
- Article
- Larval Zebrafish Use Olfactory Detection of Sodium and Chloride to Avoid Salt Water.Current biology : CB · 2021Article
- New Species Can Broaden Myelin Research: Suitability of Little Skate,Life (Basel, Switzerland) · 2021Article
- Lost structural and functional inter-relationships between Ig and TCR loci in mammals revealed in sharks.Immunogenetics · 2021Review
- Osmolarity-independent electrical cues guide rapid response to injury in zebrafish epidermis.eLife · 2020Article
- Deeply conserved synteny resolves early events in vertebrate evolution.Nature ecology & evolution · 2020Article
- Ancient Use of Ig Variable Domains Contributes Significantly to the TCRδ Repertoire.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
88 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Owing to their phylogenetic position, cartilaginous fishes (sharks, rays, skates, and chimaeras) provide a critical reference for our understanding of vertebrate genome evolution. The relatively small genome of the elephant shark, Callorhinchus milii, a chimaera, makes it an attractive model cartilaginous fish genome for whole-genome sequencing and comparative analysis. Here, the authors describe survey sequencing (1.4x coverage) and comparative analysis of the elephant shark genome, one of the first cartilaginous fish genomes to be sequenced to this depth. Repetitive sequences, represented mainly by a novel family of short interspersed element-like and long interspersed element-like sequences, account for about 28% of the elephant shark genome. Fragments of approximately 15,000 elephant shark genes reveal specific examples of genes that have been lost differentially during the evolution of tetrapod and teleost fish lineages. Interestingly, the degree of conserved synteny and conserved sequences between the human and elephant shark genomes are higher than that between human and teleost fish genomes. Elephant shark contains putative four Hox clusters indicating that, unlike teleost fish genomes, the elephant shark genome has not experienced an additional whole-genome duplication. These findings underscore the importance of the elephant shark as a critical reference vertebrate genome for comparative analysis of the human and other vertebrate genomes. This study also demonstrates that a survey-sequencing approach can be applied productively for comparative analysis of distantly related vertebrate genomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.