ArticleJournal of neural transmission (Vienna, Austria : 1996)2007
Semicarbazide-sensitive amine oxidase substrates fail to induce insulin-like effects in fat cells from AOC3 knockout mice.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Mammalian copper homeostasis: physiological roles and molecular mechanisms.Physiological reviews · 2025Review
- Oral Supplementation with Benzylamine Delays the Onset of Diabetes in Obese and Diabetic db-/- Mice.Nutrients · 2021Article
- Obesity of mice lacking VAP-1/SSAO by Aoc3 gene deletion is reproduced in mice expressing a mutated vascular adhesion protein-1 (VAP-1) devoid of amine oxidase activity.Journal of physiology and biochemistry · 2021Article
- Vanadium-dependent activation of glucose transport in adipocytes by catecholamines is not mediatedWorld journal of diabetes · 2020Article
- Zinc-α2-glycoprotein as an inhibitor of amine oxidase copper-containing 3.Open biology · 2020Article
- Methylamine Activates Glucose Uptake in Human Adipocytes Without Overpassing Action of Insulin or Stimulating its Secretion in Pancreatic Islets.Medicines (Basel, Switzerland) · 2019Article
- Resveratrol Anti-Obesity Effects: Rapid Inhibition of Adipocyte Glucose Utilization.Antioxidants (Basel, Switzerland) · 2019Article
- Copper-dependent amino oxidase 3 governs selection of metabolic fuels in adipocytes.PLoS biology · 2018Article
- Insulin-mimetic compound hexaquis (benzylammonium) decavanadate is antilipolytic in human fat cells.World journal of diabetes · 2017Article
- Combination of low dose of the anti-adipogenic agents resveratrol and phenelzine in drinking water is not sufficient to prevent obesity in very-high-fat diet-fed mice.European journal of nutrition · 2014Article
- The amine oxidase inhibitor phenelzine limits lipogenesis in adipocytes without inhibiting insulin action on glucose uptake.Journal of neural transmission (Vienna, Austria : 1996) · 2013Article
- From caffeine to fish waste: amine compounds present in food and drugs and their interactions with primary amine oxidase.Journal of neural transmission (Vienna, Austria : 1996) · 2011Article
- Increased primary amine oxidase expression and activity in white adipose tissue of obese and diabetic db-/- mice.Journal of neural transmission (Vienna, Austria : 1996) · 2011Article
- Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 deficiency reduces leukocyte infiltration into adipose tissue and favors fat deposition.The American journal of pathology · 2009Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Substrates of semicarbazide-sensitive amine oxidases (SSAO) stimulate glucose transport in adipocytes. To definitively demonstrate the involvement of SSAO in this insulin-like effect, glucose transport has been studied in fat cells from mice with a targeted deletion of AOC3, a gene encoding a SSAO called vascular adhesion protein-1. SSAO activity was present in white adipose tissues of wild type (WT) but was absent in AOC3KO mice. The SSAO-substrates benzylamine and methylamine were unable to stimulate hexose transport in adipocytes isolated from AOC3KO mice while they were active in WT adipocytes, especially in combination with vanadate. Impairment of amine-dependent glucose uptake was also observed with tyramine while there was no change in insulin responsiveness. These observations prove that the effects of exogenous or biogenic amines on glucose transport are not receptor-mediated but are oxidation-dependent. They also confirm that the major SSAO form expressed in mouse adipocytes is encoded by the AOC3 gene.
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