ArticleImmunogenetics2007
Molecular characterization of MHC class II in a nonmodel anuran species, the fire-bellied toad Bombina bombina.
Article in Immunogenetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- The Amphibian Major Histocompatibility Complex-A Review and Future Outlook.Journal of molecular evolution · 2025Review
- Southern introgression increases adaptive immune gene variability in northern range margin populations of Fire-bellied toad.Ecology and evolution · 2021Article
- Article
- Limited polymorphism of the functional MHC class II B gene in the black-spotted frog (Ecology and evolution · 2017Article
- Molecular characterization of MHC class II in the Australian invasive cane toad reveals multiple splice variants.Immunogenetics · 2016Article
- Adaptive tolerance to a pathogenic fungus drives major histocompatibility complex evolution in natural amphibian populations.Proceedings. Biological sciences · 2016Article
- Copy number variation and genetic diversity of MHC Class IIb alleles in an alien population of Xenopus laevis.Immunogenetics · 2015Article
- Susceptibility of amphibians to chytridiomycosis is associated with MHC class II conformation.Proceedings. Biological sciences · 2015Article
- Identification and characterization of major histocompatibility complex class IIB alleles from three species of European ranid frogs.Molecular biology research communications · 2014Article
- Article
- Genetic diversity of MHC class I loci in six non-model frogs is shaped by positive selection and gene duplication.Heredity · 2012Article
- MHC genotypes associate with resistance to a frog-killing fungus.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Selection, trans-species polymorphism, and locus identification of major histocompatibility complex class IIβ alleles of New World ranid frogs.Immunogenetics · 2010Article
- Towards the simplification of MHC typing protocols: targeting classical MHC class II genes in a passerine, the pied flycatcher Ficedula hypoleuca.BMC research notes · 2010Article
- Characterisation of MHC class II DRB genes in the northern tree shrew (Tupaia belangeri).Immunogenetics · 2010Article
- Balancing selection, sexual selection and geographic structure in MHC genes of Great Snipe.Genetica · 2010Article
- Species-specific evolution of class I MHC genes in iguanas (order: Squamata; subfamily: Iguaninae).Immunogenetics · 2008Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While the anuran Xenopus comprises one of the best characterized nonmammalian taxa regarding the major histocompatibility complex (MHC), the organization of this gene complex has never been studied in other anurans, and information on amphibian MHC (other than Xenopus) is generally very scarce. Here, we describe the characterization of the first MHC class II B cDNA sequences from a nonmodel anuran species, the European fire-bellied toad (Bombina bombina). We isolated two transcript sequences differing substantially in amino acid composition and length within the beta2 domain. To investigate the variability of the peptide binding region in this species, we sequenced a 158-bp large fragment from wild B. bombina (n = 20) and identified eight distinct alleles. All substitutions but one were nonsynonymous, and many of the highly polymorphic sites corresponded with amino acid positions known to be involved in antigen binding. The level of variation we found in B. bombina was similar compared to that previously found in a comparable sample of a wild urodelan species, Ambystoma tigrinum, and to that found in Xenopus laevis. Based on the cDNA data and the individual's allelic diversity, we conclude that Bombina possesses at least two class II B loci. With our new beta1 primers, we were able to generate sequences in other species of anurans. We provide here a first phylogenetic analysis of this gene in amphibians.
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