ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2008
Molecular genetics of the platelet serotonin system in first-degree relatives of patients with autism.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 60 citations in OpenAlex.
- A pharmacogenetic study of escitalopram in autism spectrum disorders.Autism research : official journal of the International Society for Autism Research · 2010Trial
- Contribution of the serotonergic system to developmental brain abnormalities in autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2024Review
- A perspective on molecular signalling dysfunction, its clinical relevance and therapeutics in autism spectrum disorder.Experimental brain research · 2022Review
- Intestinal Predictors of Whole Blood Serotonin Levels in Children With or Without Autism.Journal of autism and developmental disorders · 2022Article
- Serotonin transporter availability in adults with autism-a positron emission tomography study.Molecular psychiatry · 2021Article
- Autistic-Like Behavior and Impairment of Serotonin Transporter and AMPA Receptor Trafficking inFrontiers in genetics · 2021Article
- Brain Plasma Membrane Monoamine Transporter in Health and Disease.Handbook of experimental pharmacology · 2021Article
- Extreme enhancement or depletion of serotonin transporter function and serotonin availability in autism spectrum disorder.Pharmacological research · 2019Review
- p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The serotonin system in autism spectrum disorder: From biomarker to animal models.Neuroscience · 2016Review
- Integrin β3 Haploinsufficiency Modulates Serotonin Transport and Antidepressant-Sensitive Behavior in Mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Genetic Variation in Serotonin Transporter Modulates Tactile Hyperresponsiveness in ASD.Research in autism spectrum disorders · 2015Article
- Neuron membrane trafficking and protein kinases involved in autism and ADHD.International journal of molecular sciences · 2015Review
- Platelet studies in autism spectrum disorder patients and first-degree relatives.Molecular autism · 2015Article
- Evaluation of heritable determinants of blood and brain serotonin homeostasis using recombinant inbred mice.Genes, brain, and behavior · 2014Article
- 5-HT7 receptors as modulators of neuronal excitability, synaptic transmission and plasticity: physiological role and possible implications in autism spectrum disorders.Frontiers in cellular neuroscience · 2014Review
- N-ethylmaleimide-sensitive factor interacts with the serotonin transporter and modulates its trafficking: implications for pathophysiology in autism.Molecular autism · 2014Article
- Autism spectrum disorder associated with low serotonin in CSF and mutations in the SLC29A4 plasma membrane monoamine transporter (PMAT) gene.Molecular autism · 2014Article
- Enriched rearing improves behavioral responses of an animal model for CNV-based autistic-like traits.Human molecular genetics · 2012Article
- Brief report: Platelet-poor plasma serotonin in autism.Journal of autism and developmental disorders · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Elevated platelet serotonin (5-hydroxytryptamine, 5-HT) is found in a subset of children with autism and in some of their first-degree relatives. Indices of the platelet serotonin system, including whole blood 5-HT, 5-HT binding affinity for the serotonin transporter (K(m)), 5-HT uptake (V(max)), and lysergic acid diethylamide (LSD) receptor binding, were previously studied in 24 first-degree relatives of probands with autism, half of whom were selected for elevated whole blood 5-HT levels. All subjects were then genotyped for selected polymorphisms at the SLC6A4, HTR7, HTR2A, ITGB3, and TPH1 loci. Previous studies allowed an a priori prediction of SLC6A4 haplotypes that separated the subjects into three groups that showed significantly different 5-HT binding affinity (K(m), p=0.005) and 5-HT uptake rate (V(max), p=0.046). Genotypes at four individual polymorphisms in SLC6A4 were not associated with platelet 5-HT indices. Haplotypes at SLC6A4 and individual genotypes of polymorphisms at SLC6A4, HTR7, HTR2A, ITGB3, and TPH1 showed no significant association with whole blood 5-HT. Haplotype analysis of two polymorphisms in TPH1 revealed a nominally significant association with whole blood 5-HT (p=0.046). These initial studies of indices of the 5-HT system with several single-nucleotide polymorphisms at loci in this system generate hypotheses for testing in other samples.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.