ArticleNature protocols2006
Spectral karyotyping analysis of human and mouse chromosomes.
Article in Nature protocols, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 77 citations in OpenAlex.
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- TP53 loss initiates chromosomal instability in fallopian tube epithelial cells.Disease models & mechanisms · 2021Article
- Characterization of genetically defined sporadic and hereditary type 1 papillary renal cell carcinoma cell lines.Genes, chromosomes & cancer · 2021Article
- MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism.Cancer cell · 2021Article
- Novel renal medullary carcinoma cell lines, UOK353 and UOK360, provide preclinical tools to identify new therapeutic treatments.Genes, chromosomes & cancer · 2020Article
- Single-Cell-Derived Primary Rectal Carcinoma Cell Lines Reflect Intratumor Heterogeneity Associated with Treatment Response.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020Article
- A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice.Nature communications · 2019Article
- Single Chromosome Aneuploidy Induces Genome-Wide Perturbation of Nuclear Organization and Gene Expression.Neoplasia (New York, N.Y.) · 2019Article
- Fluorescence Multiplexing with Spectral Imaging and Combinatorics.ACS combinatorial science · 2018Article
- Long-term treatment with the PARP inhibitor niraparib does not increase the mutation load in cell line models and tumour xenografts.British journal of cancer · 2018Article
- Quantitative methods to measure aneuploidy and chromosomal instability.Methods in cell biology · 2018Article
- Genomic and metabolic characterization of a chromophobe renal cell carcinoma cell line model (UOK276).Genes, chromosomes & cancer · 2017Article
- Nuclear Pores Regulate Muscle Development and Maintenance by Assembling a Localized Mef2C Complex.Developmental cell · 2017Article
- Generation of Integration-Free Induced Pluripotent Stem Cells from Urine-Derived Cells Isolated from Individuals with Down Syndrome.Stem cells translational medicine · 2017Article
- HPV positive neuroendocrine cervical cancer cells are dependent on Myc but not E6/E7 viral oncogenes.Scientific reports · 2017Article
- Novel mouse model recapitulates genome and transcriptome alterations in human colorectal carcinomas.Genes, chromosomes & cancer · 2017Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Classical banding methods provide basic information about the identities and structures of chromosomes on the basis of their unique banding patterns. Spectral karyotyping (SKY), and the related multiplex fluorescence in situ hybridization (M-FISH), are chromosome-specific multicolor FISH techniques that augment cytogenetic evaluations of malignant disease by providing additional information and improved characterization of aberrant chromosomes that contain DNA sequences not identifiable using conventional banding methods. SKY is based on cohybridization of combinatorially labeled chromosome-painting probes with unique fluorochrome signatures onto human or mouse metaphase chromosome preparations. Image acquisition and analysis use a specialized imaging system, combining Sagnac interferometer and CCD camera images to reconstruct spectral information at each pixel. Here we present a protocol for SKY analysis using commercially available SkyPaint probes, including procedures for metaphase chromosome preparation, slide pretreatment and probe hybridization and detection. SKY analysis requires approximately 6 d.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.