ReviewMedGenMed : Medscape general medicine2006
Tackling COPD: a multicomponent disease driven by inflammation.
Review in MedGenMed : Medscape general medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- The Neutrophil-to-Lymphocyte Ratio as a Predictor of Acute Exacerbations Among Patients With COPD in Uganda.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2024Article
- Association between multidrug resistance-1 C3435T gene polymorphism and right ventricular dysfunction in patients with chronic obstructive pulmonary disease: cross-sectional study.Sao Paulo medical journal = Revista paulista de medicina · 2018Article
- Chronic obstructive pulmonary disease and low bone mass: A case-control study.Lung India : official organ of Indian Chest Society · 2014Article
- Association of polymorphisms of the receptor for advanced glycation end products gene with COPD in the Chinese population.DNA and cell biology · 2014Article
- MDR-1 gene C/T polymorphism in COPD: data from Aegean part of Turkey.International journal of clinical and experimental medicine · 2014Article
- Risk factors for asthma in a helminth endemic area in bahia, Brazil.Journal of parasitology research · 2012Article
- The effects of sleep hypoxia on coagulant factors and hepatic inflammation in emphysematous rats.PloS one · 2010Article
- Role of the CX3CL1-CX3CR1 axis in chronic inflammatory lung diseases.International journal of clinical and experimental medicine · 2010Article
- Frequency of the mdr-1 C>T gene polymorphism in patients with COPD.Clinics (Sao Paulo, Brazil) · 2010Article
- Risk of cardiac events in patients with asthma and long-QT syndrome treated with beta(2) agonists.The American journal of cardiology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, research has revealed more about the factors underlying the pathogenesis of chronic obstructive pulmonary disease (COPD). In particular, inflammation in the lungs leads to the structural changes observed in COPD, while extrapulmonary symptoms and comorbidities may be systemic manifestations of these inflammatory processes. A new multicomponent disease model is proposed that takes into account all elements that should be considered in treatment decisions. Current monotherapies act on different aspects of COPD and may not address all components. A combination of a long-acting beta2 agonist and an inhaled corticosteroid has complementary effects, addressing a wider range of components of COPD. This combination appears to have greater clinical benefits than either agent alone in reducing the frequency of exacerbations, reducing the number of hospitalizations, and potentially promoting survival. Minimizing the burden of COPD within--and potentially outside--the lung means treating patients early and addressing as many disease components as possible.
Indexed as
Identifiers
17406181PMC1781317What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.