ArticleDigestive diseases and sciences2007
Metallothionein expression in Helicobacter-infected pregnant mice and their fetuses and pups.
Article in Digestive diseases and sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Molecular characterization of Treponema denticola infection-induced bone and soft tissue transcriptional profiles.Molecular oral microbiology · 2010Article
- Manipulations of metallothionein gene dose accelerate the response to Listeria monocytogenes.Chemico-biological interactions · 2009Article
- Association between Helicobacter pylori infection in mothers and birth weight.Digestive diseases and sciences · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metallothionein (MT) expression was investigated in pregnant mice infected with H. pylori or H. felis and their fetuses and pups. Mice, healthy or infected with H. pylori or H. felis (n = 18/group), were sacrificed 2 weeks after impregnation or 4 weeks postpartum. Pups were sacrificed as fetuses, after birth, or at ages 11 or 28 days. Whole fetuses, stomachs, small intestines, and livers were assayed for MT. MT was increased (P<0.05) by two- and threefold in fetuses from H. pylori- and H. felis-infected mothers, respectively, compared to control fetuses. Stomach MT of H. felis-infected pregnant mice, and newborns and 28-day pups from H. felis-infected mothers, was elevated (P<0.05) twofold compared to that of control mice and pups. Liver MT was decreased (P<0.05) in H. felis-infected mice 4 weeks postpartum (18%) and in their 11-day (69%) and 28-day (53%) pups, while small intestinal MT was decreased in H. felis-infected pregnant mice (17%), H. felis-infected mice 4 weeks postpartum (19%), and their 11-day pups (35%), compared to control mice. H. felis infection altered MT levels of pregnant mice, their fetuses and pups, and mice postpartum, which may be a response to the marked inflammation.
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Registered trials
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