ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2007
Laboratory-based surveillance of patients with bacterial meningitis in Egypt (1998-2004).
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Sex differences in bacterial meningitis and associations with socioeconomic indicators: a systematic review and meta-analysis with metaregression.BMJ global health · 2025Pooled it
- Pneumococcal disease in children in the Middle East and Northern Africa: A systematic literature review of clinical burden, serotype distribution, and vaccination programs.Human vaccines & immunotherapeutics · 2024Pooled it
- Global Case Fatality of Bacterial Meningitis During an 80-Year Period: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Systematic review of invasive meningococcal disease epidemiology in the Eastern Mediterranean and North Africa region.BMC infectious diseases · 2021Pooled it
- Meningococcal disease within the Gulf Cooperation Council Countries.Human vaccines & immunotherapeutics · 2023Review
- Meningococcal Disease and Immunization Activities in Hajj and Umrah Pilgrimage: a review.Infectious diseases and therapy · 2022Review
- Use of a new multiplex quantitative polymerase chain reaction based assay for simultaneous detection ofIranian journal of microbiology · 2021Article
- Microbial aspects and potential markers for differentiation between bacterial and viral meningitis among adult patients.PloS one · 2021Article
- Evaluation of the BioFire FilmArray meningitis/encephalitis panel for the detection of bacteria and yeast in Chinese children.Annals of translational medicine · 2019Article
- Challenges and opportunities for meningococcal vaccination in the developing world.Human vaccines & immunotherapeutics · 2018Review
- Evaluation of the enhanced meningitis surveillance system, Yendi municipality, northern Ghana, 2010-2015.BMC infectious diseases · 2017Article
- Prevalence of MDR pathogens of bacterial meningitis in Egypt and new synergistic antibiotic combinations.PloS one · 2017Article
- Incidence and etiology of hospitalized acute respiratory infections in the Egyptian Delta.Influenza and other respiratory viruses · 2017Article
- Emergence of Neoteric Serotypes Among Multidrug Resistant Strains of Streptococcus pneumoniae Prevalent in Egypt.Jundishapur journal of microbiology · 2016Article
- Development and evaluation of a novel vaccine against prevalent invasive multi-drug resistant strains ofPeerJ · 2016Article
- Identification of Common Bacterial Pathogens Causing Meningitis in Culture-Negative Cerebrospinal Fluid Samples Using Real-Time Polymerase Chain Reaction.International journal of microbiology · 2016Article
- Article
- Role of Clinical Presentations and Routine CSF Analysis in the Rapid Diagnosis of Acute Bacterial Meningitis in Cases of Negative Gram Stained Smears.Journal of tropical medicine · 2014Article
- Aetiological agents of cerebrospinal meningitis: a retrospective study from a teaching hospital in Ghana.Annals of clinical microbiology and antimicrobials · 2012Article
- A situational analysis of antimicrobial drug resistance in Africa: are we losing the battle?Ethiopian journal of health sciences · 2012Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laboratory-based surveillance for bacterial meningitis was conducted in a network of infectious disease hospitals in Egypt to better understand the epidemiology of this infection. Healthcare and laboratory personnel were trained in basic surveillance and microbiologic processing of cerebrospinal fluid (CSF) specimens. All bacterial isolates from CSF were confirmed and tested for antimicrobial susceptibility. PCR testing was performed on a random subset of purulent, culture-negative CSF specimens. Of 11,070 patients who met criteria for the case definition, 843 (8%) were culture positive (42% positive for Streptococcus pneumoniae, 20% for Haemophilus influenzae serotype b, 17% for each of Neisseria meningitidis and Mycobacterium tuberculosis, and 6% for other bacteria). Of 1,784 (46%) CSF specimens tested by PCR, 232 (13%) were positive for the first three major pathogens. Of N. meningitidis isolates, 52% belonged to serogroup A, 35% to serogroup B, and 4% to serogroup W135. S. pneumoniae isolates comprised 46 different serotypes, of which 6B, 1, 19A, 23F, and 6A were the most predominant. The overall case-fatality rate for culture-positive cases was 26% and was highest among patients with M. tuberculosis (47%). Factors significantly associated with death (p < 0.05) included admission to rural hospitals, long prodromal period, referral from other hospitals, antibiotic treatment prior to admission, and clear CSF (<100 cells/mm3). Susceptibility to ampicillin and ceftriaxone was observed in 44 and 100% of H. influenzae serotype b isolates and in 52 and 94% of S. pneumoniae isolates, respectively. This surveillance highlights the significant mortality and morbidity associated with bacterial meningitis in Egypt. Decision makers need to review current treatment guidelines and introduce appropriate vaccines for prevention and control of the disease.
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