ReviewChromosoma2007
Replication origin plasticity, Taylor-made: inhibition vs recruitment of origins under conditions of replication stress.
Review in Chromosoma, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed.
- NFIB facilitates replication licensing by acting as a genome organizer.Nature communications · 2023Article
- Detection and characterization of constitutive replication origins defined by DNA polymerase epsilon.BMC biology · 2023Article
- LSD1 is required for euchromatic origin firing and replication timing.Signal transduction and targeted therapy · 2022Article
- Mind the replication gap.Royal Society open science · 2021Review
- Sonic hedgehog accelerates DNA replication to cause replication stress promoting cancer initiation in medulloblastoma.Nature cancer · 2020Article
- Arabidopsis DNA Replication Initiates in Intergenic, AT-Rich Open Chromatin.Plant physiology · 2020Article
- SUV4-20 activity in the preimplantation mouse embryo controls timely replication.Genes & development · 2016Article
- Replicating Large Genomes: Divide and Conquer.Molecular cell · 2016Review
- 3D replicon distributions arise from stochastic initiation and domino-like DNA replication progression.Nature communications · 2016Article
- The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damage.Nature communications · 2015Article
- Peaks cloaked in the mist: the landscape of mammalian replication origins.The Journal of cell biology · 2015Review
- Activation of new replication foci under conditions of replication stress.Cell cycle (Georgetown, Tex.) · 2015Article
- Replication forks reverse at high frequency upon replication stress in Physarum polycephalum.Chromosoma · 2014Article
- Best practices for mapping replication origins in eukaryotic chromosomes.Current protocols in cell biology · 2014Review
- Replication origin selection regulates the distribution of meiotic recombination.Molecular cell · 2014Article
- Relationship between DNA damage response, initiated by camptothecin or oxidative stress, and DNA replication, analyzed by quantitative 3D image analysis.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2013Article
- Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress.Oncogene · 2013Article
- Human SIRT1 regulates DNA binding and stability of the Mcm10 DNA replication factor via deacetylation.Nucleic acids research · 2013Article
- Dormant origins, the licensing checkpoint, and the response to replicative stresses.Cold Spring Harbor perspectives in biology · 2012Review
- Broader utilization of origins of DNA replication in cancer cell lines along a 78 kb region of human chromosome 2q34.Journal of cellular biochemistry · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among his many contributions to the field of chromosome structure and dynamics, J. Herbert Taylor showed that eukaryotic cells have many more potential replication origins than they use, which they can recruit when replication forks are slowed to complete S-phase in a timely fashion. Thirty years later, his findings raise an important but largely overlooked paradox. Although new data have confirmed his results, a larger body of data has revealed that slowing replication forks activates an S-phase checkpoint cascade that inhibits initiation from unfired origins until the stress is relieved. In this paper, in celebration of Taylor's work published in Chromosoma 30 years ago, I draw attention to this paradox and offer some plausible models to explain how replication stress can both inhibit and recruit new origins. I hope that this essay will stimulate further experimentation into the basis of Taylor's original findings.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.