ArticleEuropean radiology2007
Diffusion-weighted imaging in normal fetal brain maturation.
Article in European radiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 111 citations in OpenAlex.
- Insights into temporal and spatial dynamics of short association fiber formation in the human fetal brain.Science advances · 2026Article
- Fundamentals of fetal brain MRI: indications, technique, and normal anatomy.Pediatric radiology · 2026Review
- Diffusion-weighted imaging of the spinal cord in children after prenatal myelomeningocele repair.Pediatric radiology · 2026Article
- Association between fetal brain diffusion-weighted imaging and postnatal neurodevelopmental outcome after prenatal myelomeningocele repair.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026Article
- Evaluation of brain microstructure changes in surviving fetus of monochorionic twin pregnancies with single intrauterine fetal death using diffusion weighted imaging: a MRI-based cohort study.BMC medical imaging · 2025Article
- Sex differences in normal fetal regional brain apparent diffusion coefficient changes assessed byFrontiers in pediatrics · 2024Article
- Cerebral microstructural changes in children suffering from hemolytic uremic syndrome.European journal of pediatrics · 2023Article
- ADC values as a biomarker of fetal brain maturation.Radiology and oncology · 2023Article
- Regional changes in brain apparent diffusion coefficient in fetuses with complex congenital heart disease and normal pregnancy assessed using diffusion-weighted imaging.Frontiers in neurology · 2023Article
- 3.0 Tesla normative diffusivity in 3rd trimester fetal brain.Neuroradiology · 2022Article
- DWI in Brains of Fetuses with Congenital Heart Disease: A Case-Control MR Imaging Study.AJNR. American journal of neuroradiology · 2021Article
- Brain fetal magnetic resonance imaging to evaluate maturation of normal white matter during the third trimester of pregnancy.Pediatric radiology · 2021Article
- Deuterium Magnetic Resonance Imaging and the Discrimination of Fetoplacental Metabolism in Normal and L-NAME-Induced Preeclamptic Mice.Metabolites · 2021Article
- Development of human white matter pathways in utero over the second and third trimester.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The Influence of Various Cerebral and Extracerebral Pathologies on Apparent Diffusion Coefficient Values in the Fetal Brain.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2020Article
- Development of Brain Networks In Utero: Relevance for Common Neural Disorders.Biological psychiatry · 2020Review
- Apparent diffusion coefficient of different areas of brain in foetuses with intrauterine growth restriction.Polish journal of radiology · 2020Article
- Direct comparison between apparent diffusion coefficient and macromolecular proton fraction as quantitative biomarkers of the human fetal brain maturation.Journal of magnetic resonance imaging : JMRI · 2019Article
- Apparent Diffusion Coefficient Levels and Neurodevelopmental Outcome in Fetuses with Brain MR Imaging White Matter Hyperintense Signal.AJNR. American journal of neuroradiology · 2018Article
- Quantitative Assessment of Normal Fetal Brain Myelination Using Fast Macromolecular Proton Fraction Mapping.AJNR. American journal of neuroradiology · 2018Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diffusion-weighted imaging (DWI) provides information about tissue maturation not seen on conventional magnetic resonance imaging. The aim of this study is to analyze the evolution over time of the apparent diffusion coefficient (ADC) of normal fetal brain in utero. DWI was performed on 78 fetuses, ranging from 23 to 37 gestational weeks (GW). All children showed at follow-up a normal neurological evaluation. ADC values were obtained in the deep white matter (DWM) of the centrum semiovale, the frontal, parietal, occipital and temporal lobe, in the cerebellar hemisphere, the brainstem, the basal ganglia (BG) and the thalamus. Mean ADC values in supratentorial DWM areas (1.68 +/- 0.05 mm(2)/s) were higher compared with the cerebellar hemisphere (1.25 +/- 0.06 mm(2)/s) and lowest in the pons (1.11 +/- 0.05 mm(2)/s). Thalamus and BG showed intermediate values (1.25 +/- 0.04 mm(2)/s). Brainstem, cerebellar hemisphere and thalamus showed a linear negative correlation with gestational age. Supratentorial areas revealed an increase in ADC values, followed by a decrease after the 30th GW. This study provides a normative data set that allows insights in the normal fetal brain maturation in utero, which has not yet been observed in previous studies on premature babies.
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