ArticleThe Journal of cell biology1992
The desmoplakin carboxyl terminus coaligns with and specifically disrupts intermediate filament networks when expressed in cultured cells.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 195 citations in OpenAlex.
- Desmosomes compartmentalize mRNA and translation in the skin.Developmental cell · 2026Article
- Binding of the periplakin linker requires vimentin acidic residues D176 and E187.Communications biology · 2020Article
- Intermediate Filaments and the Plasma Membrane.Cold Spring Harbor perspectives in biology · 2017Review
- Physiological Functions of the Cellular Prion Protein.Frontiers in molecular biosciences · 2017Review
- Article
- Cell adhesion in epidermal development and barrier formation.Current topics in developmental biology · 2015Review
- Mechanistic basis of desmosome-targeted diseases.Journal of molecular biology · 2013Review
- Desmoplakin controls microvilli length but not cell adhesion or keratin organization in the intestinal epithelium.Molecular biology of the cell · 2012Article
- Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis.The Journal of cell biology · 2011Article
- The calcium ATPase SERCA2 regulates desmoplakin dynamics and intercellular adhesive strength through modulation of PKCα signaling.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
- Identification and characterization of DSPIa, a novel isoform of human desmoplakin.Cell and tissue research · 2010Article
- Compound heterozygous desmoplakin mutations result in a phenotype with a combination of myocardial, skin, hair, and enamel abnormalities.The Journal of investigative dermatology · 2010Article
- Desmosomes in vivo.Dermatology research and practice · 2010Article
- Ordered assembly of the adhesive and electrochemical connections within newly formed intercalated disks in primary cultures of adult rat cardiomyocytes.Journal of biomedicine & biotechnology · 2010Article
- Interactions of plakoglobin and beta-catenin with desmosomal cadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes.The Journal of biological chemistry · 2009Article
- Periplakin interactions with lens intermediate and beaded filaments.Investigative ophthalmology & visual science · 2009Article
- The desmosome and pemphigus.Histochemistry and cell biology · 2008Review
- Desmoplakin: an unexpected regulator of microtubule organization in the epidermis.The Journal of cell biology · 2007Article
- Loss of desmoplakin isoform I causes early onset cardiomyopathy and heart failure in a Naxos-like syndrome.Journal of medical genetics · 2006Article
- Desmoplakin assembly dynamics in four dimensions: multiple phases differentially regulated by intermediate filaments and actin.The Journal of cell biology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Specific interactions between desmoplakins I and II (DP I and II) and other desmosomal or cytoskeletal molecules have been difficult to determine in part because of the complexity and insolubility of the desmosome and its constituents. We have used a molecular genetic approach to investigate the role that DP I and II may play in the association of the desmosomal plaque with cytoplasmic intermediate filaments (IF). A series of mammalian expression vectors encoding specific predicted domains of DP I were transiently expressed in cultured cells that form (COS-7) and do not form (NIH-3T3) desmosomes. Sequence encoding a small antigenic peptide was added to the 3' end of each mutant DP cDNA to facilitate immunolocalization of mutant DP protein. Light and electron microscopical observations revealed that DP polypeptides including the 90-kD carboxy-terminal globular domain of DP I specifically colocalized with and ultimately resulted in the complete disruption of IF in both cell lines. This effect was specific for IF as microtubule and microfilament networks were unaltered. This effect was also specific for the carboxyl terminus of DP, as the expression of the 95-kD rod domain of DP I did not visibly alter IF networks. Immunogold localization of COS-7 cells transfected with constructs including the carboxyl terminus of DP demonstrated an accumulation of mutant protein in perinuclear aggregates within which IF subunits were sequestered. These results suggest a role for the DP carboxyl terminus in the attachment of IF to the desmosome in either a direct or indirect manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.