ArticleAutophagy
The autophagic pathway: a cell survival strategy against the bacterial pore-forming toxin Vibrio cholerae cytolysin.
Article in Autophagy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Enigmatic roles ofJournal of bacteriology · 2025Review
- Autophagy in oral cancer: Promises and challenges (Review).International journal of molecular medicine · 2024Review
- Phenol-Soluble Modulin α3 Stimulates Autophagy in HaCaT Keratinocytes.Biomedicines · 2023Article
- Intracellular Degradation of Helicobacter pylori VacA Toxin as a Determinant of Gastric Epithelial Cell Viability.Infection and immunity · 2019Article
- Mechanisms protecting host cells against bacterial pore-forming toxins.Cellular and molecular life sciences : CMLS · 2019Review
- Response of Cellular Innate Immunity to Cnidarian Pore-Forming Toxins.Molecules (Basel, Switzerland) · 2018Review
- c-Jun Proto-Oncoprotein Plays a Protective Role in Lung Epithelial Cells Exposed to Staphylococcal α-Toxin.Frontiers in cellular and infection microbiology · 2018Article
- Glucosyltransferase Activity of Clostridium difficile Toxin B Triggers Autophagy-mediated Cell Growth Arrest.Scientific reports · 2017Article
- A Novel Role ofFrontiers in cellular and infection microbiology · 2017Article
- Signaling beyond Punching Holes: Modulation of Cellular Responses by Vibrio cholerae Cytolysin.Toxins · 2015Review
- Modulation of translation and induction of autophagy by bacterial exoproducts.Medical microbiology and immunology · 2012Review
- A subunit of eukaryotic translation initiation factor 2α-phosphatase (CreP/PPP1R15B) regulates membrane traffic.The Journal of biological chemistry · 2012Article
- Genomic analysis of immune response against Vibrio cholerae hemolysin in Caenorhabditis elegans.PloS one · 2012Article
- Autophagy: a primer for the gastroenterologist/hepatologist.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2011Review
- Pro-autophagic signal induction by bacterial pore-forming toxins.Medical microbiology and immunology · 2010Article
- Vibrio cholerae hemolysin is required for lethality, developmental delay, and intestinal vacuolation in Caenorhabditis elegans.PloS one · 2010Article
- Listeriolysin O is necessary and sufficient to induce autophagy during Listeria monocytogenes infection.PloS one · 2010Article
- The Vibrio cholerae cytolysin promotes chloride secretion from intact human intestinal mucosa.PloS one · 2009Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vibrio cholerae is the causative agent of cholera in humans. In addition to the criticalvirulence factors cholera toxin and toxin coregulated pilus, V. cholerae secretes V.cholerae cytolysin (VCC), a pore-forming exotoxin able to induce cell lysis and extensivevacuolation. We have shown that this vacuolation is related to the activation of autophagyin response to VCC action. Furthermore, we found that the autophagic pathway wasrequired to protect cells upon VCC intoxication. Based on additional data presented here,we propose a model aimed to explain the mechanism of cell protection. We postulatethat VCC-induced autophagic vacuoles, which display features of multivesicular bodies and enclose the toxin, are implicated in cell defense through VCC degradation involvingfusion with lysosomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.