ArticleJournal of immunology (Baltimore, Md. : 1950)2007
CD8+ T cell dysfunction and increase in murine gammaherpesvirus latent viral burden in the absence of 4-1BB ligand.
Article in Journal of immunology (Baltimore, Md. : 1950), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- 4-1BB immunotherapy: advances and hurdles.Experimental & molecular medicine · 2024Review
- Inherited TNFSF9 deficiency causes broad Epstein-Barr virus infection with EBV+ smooth muscle tumors.The Journal of experimental medicine · 2022Article
- Elevated soluble 4-1BB is associated with serum markers of hepatitis B virus in patients with chronic hepatitis B.World journal of clinical cases · 2021Article
- The Murine CD137/CD137 Ligand Signalosome: A Signal Platform Generating Signal Complexity.Frontiers in immunology · 2020Review
- CD137 Plays Both Pathogenic and Protective Roles in Type 1 Diabetes Development in NOD Mice.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Article
- T-cell costimulatory blockade in organ transplantation.Cold Spring Harbor perspectives in medicine · 2013Review
- CD8(+) T cells from mice transnuclear for a TCR that recognizes a single H-2K(b)-restricted MHV68 epitope derived from gB-ORF8 help control infection.Cell reports · 2012Article
- CD27 stimulation promotes the frequency of IL-7 receptor-expressing memory precursors and prevents IL-12-mediated loss of CD8(+) T cell memory in the absence of CD4(+) T cell help.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis.Immunology and cell biology · 2012Article
- Dispensable role for 4-1BB and 4-1BBL in development of vaccinia virus-specific CD8 T cells.Immunology letters · 2012Article
- Targeting 4-1BB (CD137) to enhance CD8 T cell responses with poxviruses and viral antigens.Frontiers in immunology · 2012Article
- Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8(+) T cells.European journal of immunology · 2010Article
- Opposing positive and negative regulation of T cell activity during viral persistence.Current opinion in immunology · 2010Review
- Tumor necrosis factor receptor/tumor necrosis factor family members in antiviral CD8 T-cell immunity.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2010Review
- Perturbation of lytic and latent gammaherpesvirus infection in the absence of the inhibitory receptor CEACAM1.PloS one · 2009Article
- Cutting edge: IL-2 immune complexes as a therapy for persistent virus infection.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- The diversity of costimulatory and inhibitory receptor pathways and the regulation of antiviral T cell responses.Current opinion in immunology · 2009Review
- Costimulation signals for memory CD8+ T cells during viral infections.Critical reviews in immunology · 2009Review
- Primary clearance of murine gammaherpesvirus 68 by PKCtheta-/- CD8 T cells is compromised in the absence of help from CD4 T cells.Journal of virology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Studies of costimulatory receptors belonging to the TNFR family have revealed their diverse roles in affecting different stages of the T cell response. The 4-1BB ligand (4-1BBL)/4-1BB pathway has emerged as a receptor-ligand pair that impacts not the initial priming, but later phases of the T cell response, such as sustaining clonal expansion and survival, maintaining memory CD8(+) T cells, and supporting secondary expansion upon Ag challenge. Although the role of this costimulatory pathway in CD8(+) T cell responses to acute viral infections has been well-studied, its role in controlling chronic viral infections in vivo is not known to date. Using the murine gammaherpesvirus-68 (MHV-68) model, we show that 4-1BBL-deficient mice lack control of MHV-68 during latency and show significantly increased latent viral loads. In contrast to acute influenza infection, the numbers of MHV-68-specific memory CD8(+) T cells were maintained during latency. However, the virus-specific CD8(+) T cells showed defects in function, including decreased cytolytic function and impaired secondary expansion. Thus, 4-1BBL deficiency significantly affects the function, but not the number, of virus-specific CD8(+) T cells during gammaherpesvirus latency, and its absence results in an increased viral burden. Our study suggests that the 4-1BB costimulatory pathway plays an important role in controlling chronic viral infections.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.