ArticleJournal of immunology (Baltimore, Md. : 1950)2007
Dendritic cells from lupus-prone mice are defective in repressing immunoglobulin secretion.
Article in Journal of immunology (Baltimore, Md. : 1950), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Dendritic Cells Regulate Extrafollicular Autoreactive B Cells via T Cells Expressing Fas and Fas Ligand.Immunity · 2016Article
- Breakdown of Immune Tolerance in Systemic Lupus Erythematosus by Dendritic Cells.Journal of immunology research · 2016Review
- Enhanced activation of dendritic cells by autologous apoptotic microvesicles in MRL/lpr mice.Arthritis research & therapy · 2015Article
- Autoreactive preplasma cells break tolerance in the absence of regulation by dendritic cells and macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Potentially autoreactive naturally occurring transitional T3 B lymphocytes exhibit a unique signaling profile.Journal of autoimmunity · 2012Article
- Activation-induced deaminase-deficient MRL/lpr mice secrete high levels of protective antibodies against lupus nephritis.Arthritis and rheumatism · 2011Article
- Dendritic cells in systemic lupus erythematosus.International reviews of immunology · 2010Review
- The regulation of autoreactive B cells during innate immune responses.Immunologic research · 2008Article
- Macrophages prevent the differentiation of autoreactive B cells by secreting CD40 ligand and interleukin-6.Blood · 2007Article
- B-cell anergy: from transgenic models to naturally occurring anergic B cells?Nature reviews. Immunology · 2007Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Autoimmunity results from a breakdown in tolerance mechanisms that regulate autoreactive lymphocytes. We recently showed that during innate immune responses, secretion of IL-6 by dendritic cells (DCs) maintained autoreactive B cells in an unresponsive state. In this study, we describe that TLR4-activated DCs from lupus-prone mice are defective in repressing autoantibody secretion, coincident with diminished IL-6 secretion. Reduced secretion of IL-6 by MRL/lpr DCs reflected diminished synthesis and failure to sustain IL-6 mRNA production. This occurred coincident with lack of NF-kappaB and AP-1 DNA binding and failure to sustain IkappaBalpha phosphorylation. Analysis of individual mice showed that some animals partially repressed Ig secretion despite reduced levels of IL-6. This suggests that in addition to IL-6, DCs secrete other soluble factor(s) that regulate autoreactive B cells. Collectively, the data show that MRL/lpr mice are defective in DC/IL-6-mediated tolerance, but that some individuals maintain the ability to repress autoantibody secretion by an alternative mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.