Trial reportAntimicrobial agents and chemotherapy2007
Controlled trial of a 5-day course of telithromycin versus doxycycline for treatment of mild to moderate scrub typhus.
Trial report in Antimicrobial agents and chemotherapy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Evaluation of the Therapeutic Effect of Antibiotics on Scrub Typhus: A Systematic Review and Network Meta-Analysis.Frontiers in public health · 2022Pooled it
- Systematic review of the scrub typhus treatment landscape: Assessing the feasibility of an individual participant-level data (IPD) platform.PLoS neglected tropical diseases · 2021Pooled it
- Antibiotics for treating scrub typhus.The Cochrane database of systematic reviews · 2018Pooled it
- Tigecycline versus doxycycline for scrub typhus: a preliminary randomized trial.Tropical medicine and health · 2026Article
- Atypical presentation and response to treatment in scrub typhus: a series of 2 cases.Sudanese journal of paediatrics · 2024Article
- Carbohydrate-based drugs launched during 2000Acta pharmaceutica Sinica. B · 2022Review
- Efficacy and Safety of Antibiotics for Treatment of Scrub Typhus: A Network Meta-analysis.JAMA network open · 2020Article
- Case Report: Scrub Typhus and Q Fever Coinfection.The American journal of tropical medicine and hygiene · 2019Article
- Clinical and paraclinical profile, and predictors of outcome in 90 cases of scrub typhus, Meghalaya, India.Infectious diseases of poverty · 2016Article
- Severe scrub typhus infection: Clinical features, diagnostic challenges and management.World journal of critical care medicine · 2015Review
- DHR-ICMR Guidelines for diagnosis & management of Rickettsial diseases in India.The Indian journal of medical research · 2015Article
- Rickettsial infections in Southeast Asia: implications for local populace and febrile returned travelers.The American journal of tropical medicine and hygiene · 2014Review
- Outcome of intravenous azithromycin therapy in patients with complicated scrub typhus compared with that of doxycycline therapy using propensity-matched analysis.Antimicrobial agents and chemotherapy · 2014Article
- A comparative study of hepatitis caused by scrub typhus and viral hepatitis A in South Korea.The American journal of tropical medicine and hygiene · 2011Article
- Comparison of conventional, nested, and real-time quantitative PCR for diagnosis of scrub typhus.Journal of clinical microbiology · 2011Article
- Association of high Orientia tsutsugamushi DNA loads with disease of greater severity in adults with scrub typhus.Journal of clinical microbiology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
New antibiotics are required to have the antibacterial activity against doxycycline-resistant Orientia tsutsugamushi. An in vitro sensitivity study showed that telithromycin was more effective than erythromycin for Rickettsia, Bartonella, and Coxiella burnetii. In this prospective, open-label, randomized trial, we enrolled patients with mild-to-moderate scrub typhus. We compared the efficacy and safety of a 5-day telithromycin therapy with those of a 5-day doxycycline therapy at Chosun University Hospital or one of its two community-based affiliated hospitals (Jangheung Hospital and Cheomdan Hospital), which are all located in southwestern Korea, between September and December 2005. A total of 92 patients were randomly assigned to either the telithromycin group (n = 47) or the doxycycline group (n = 45). After the treatment, fever control time was 20.45 +/- 12.9 h in the telithromycin group and 22.60 +/- 21.44 h in the doxycycline group (P > 0.05). After the treatment, the cure rate was 100% in the telithromycin group and 97.8% in the doxycycline group (P > 0.05). Furthermore, there were no significant differences in time elapsed until such symptoms as headache, myalgia, and rash disappeared. No serious adverse events or death were noted following the treatment in both groups. There were no significant differences in adverse events. In conclusion, the efficacy and safety of a 5-day once-a-day regimen of 800 mg telithromycin were equivalent to those of a 5-day twice-a-day regimen of 100 mg doxycycline in patients with mild-to-moderate scrub typhus. Telithromycin could be considered a promising new antibacterial agent for patients with scrub typhus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.