ReviewPostgraduate medical journal2007
DNA sequence variations of metalloproteinases: their role in asthma and COPD.
Review in Postgraduate medical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Matrix metalloproteinase-9 -1562C/T promoter polymorphism confers risk for COPD: a meta-analysis.PloS one · 2013Pooled it
- Effects of liver X receptor in O3-induced airway inflammation and remodeling in mice.Journal of thoracic disease · 2024Article
- The strong correlation between ADAM33 expression and airway inflammation in chronic obstructive pulmonary disease and candidate for biomarker and treatment of COPD.Scientific reports · 2021Article
- Article
- Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma.Allergy, asthma & immunology research · 2019Review
- Protective Effect of Jianpiyifei II Granule against Chronic Obstructive Pulmonary Disease via NF-Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Airway Remodeling in Chronic Obstructive Pulmonary Disease and Asthma: the Role of Matrix Metalloproteinase-9.Archivum immunologiae et therapiae experimentalis · 2016Review
- Association of ADAM33 gene polymorphisms with psoriasis in a northeastern Chinese population.Molecular biology reports · 2014Article
- Epidemiology of virus-induced asthma exacerbations: with special reference to the role of human rhinovirus.Frontiers in microbiology · 2014Review
- Cell therapy with bone marrow mononuclear cells in elastase-induced pulmonary emphysema.Stem cell reviews and reports · 2013Article
- The Effect of Doxycycline on PMA-Induced MUC5B Expression via MMP-9 and p38 in NCI-H292 Cells.Clinical and experimental otorhinolaryngology · 2011Article
- Association of ADAM33 gene with susceptibility to COPD in Tibetan population of China.Molecular biology reports · 2011Article
- Genetic evidence linking lung cancer and COPD: a new perspective.The application of clinical genetics · 2011Article
- Molecular targets and therapeutic potential of baicalein: a review.Drug target insightsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asthma and chronic obstructive pulmonary disease (COPD) are complex genetic diseases that cause considerable morbidity and mortality worldwide. Genetic variability interacting with environmental and ethnic factors is presumed to cause tobacco smoke susceptibility and to influence asthma severity. A disintegrin and metalloproteinase 33 (ADAM33) and matrix metalloproteinase-9 (MMP9) appear to have important roles in asthma and COPD pathogenesis. ADAM33 and MMP9 genetic alterations could possibly contribute to the establishment and progression of these multifactorial diseases, although their association with the clinical phenotypes has not yet been elucidated. However, the occurrence of these alterations does not always result in clear disease, implying that either they are an epiphenomenon or they are in proximity to the true causative alteration. This review summarises the most recent literature dealing with the genetic variations of metalloproteinases and outlines their potential pathogenetic outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.