ArticleThe Journal of experimental medicine2007
Repression of BCL-6 is required for the formation of human memory B cells in vitro.
Article in The Journal of experimental medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 82 citations in OpenAlex.
- Importance of B cells (Review).International journal of molecular medicine · 2026Review
- Interleukin-4 downregulates transcription factor BCL6 to promote memory B cell selection in germinal centers.Immunity · 2024Article
- ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis.Cancer cell · 2024Article
- Examining B-cell dynamics and responsiveness in different inflammatory milieus using an agent-based model.PLoS computational biology · 2024Article
- Transcriptional regulation of memory B cell differentiation.Nature reviews. Immunology · 2021Review
- Id3 and Bcl6 Promote the Development of Long-Term Immune Memory Induced by Tuberculosis Subunit Vaccine.Vaccines · 2021Article
- Exit from germinal center to become quiescent memory B cells depends on metabolic reprograming and provision of a survival signal.The Journal of experimental medicine · 2021Article
- System-Level Scenarios for the Elucidation of T Cell-Mediated Germinal Center B Cell Differentiation.Frontiers in immunology · 2021Review
- Article
- Gammaherpesviruses and B Cells: A Relationship That Lasts a Lifetime.Viral immunology · 2020Review
- Effect of follicular helper T cells on the pathogenesis of asthma.Experimental and therapeutic medicine · 2017Article
- Naïve and memory B cells exhibit distinct biochemical responses following BCR engagement.Immunology and cell biology · 2016Article
- A Network Model to Describe the Terminal Differentiation of B Cells.PLoS computational biology · 2016Article
- Article
- Epigenetic Regulation of Antibody Responses by the Histone H2A Deubiquitinase MYSM1.Scientific reports · 2015Article
- Article
- Epigenetics of the antibody response.Trends in immunology · 2013Review
- New effector functions and regulatory mechanisms of BCL6 in normal and malignant lymphocytes.Current opinion in immunology · 2013Review
- IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- MicroRNAs and Glucocorticoid-Induced Apoptosis in Lymphoid Malignancies.ISRN hematology · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Memory B cells provide rapid protection to previously encountered antigens; however, how these cells develop from germinal center B cells is not well understood. A previously described in vitro culture system using human tonsillar germinal center B cells was used to study the transcriptional changes that occur during differentiation of human memory B cells. Kinetic studies monitoring the expression levels of several known late B cell transcription factors revealed that BCL-6 is not expressed in memory B cells generated in vitro, and gene expression profiling studies confirmed that BCL-6 is not expressed in these memory B cells. Furthermore, ectopic expression of BCL-6 in human B cell cultures resulted in formation of fewer memory B cells. In addition, the expression profile of in vitro memory B cells showed a unique pattern that includes expression of genes encoding multiple costimulatory molecules and cytokine receptors, antiapoptotic proteins, T cell chemokines, and transcription factors. These studies establish new molecular criteria for defining the memory B cell stage in human B cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.