ArticleThe Journal of experimental medicine2007
A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d.
Article in The Journal of experimental medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Contribution of NKT cells and CD1d-expressing cells in obesity-associated adipose tissue inflammation.Frontiers in immunology · 2024Review
- CD1-mediated immune responses in mucosal tissues: molecular mechanisms underlying lipid antigen presentation system.Experimental & molecular medicine · 2023Review
- Sortase A-Cleavable CD1d Identifies Sphingomyelins as Major Class of CD1d-Associated Lipids.Frontiers in immunology · 2022Article
- Sterile activation of invariant natural killer T cells by ER-stressed antigen-presenting cells.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- CD1d-Restricted pathways in hepatocytes control local natural killer T cell homeostasis and hepatic inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Activation strategies for invariant natural killer T cells.Immunogenetics · 2016Review
- The processing and presentation of lipids and glycolipids to the immune system.Immunological reviews · 2016Review
- CD1-Restricted T Cells at the Crossroad of Innate and Adaptive Immunity.Journal of immunology research · 2016Review
- Mice subjected to aP2-Cre mediated ablation of microsomal triglyceride transfer protein are resistant to high fat diet induced obesity.Nutrition & metabolism · 2016Article
- The CD1 size problem: lipid antigens, ligands, and scaffolds.Cellular and molecular life sciences : CMLS · 2014Review
- Invariant natural killer T cells in adipose tissue: novel regulators of immune-mediated metabolic disease.Cellular and molecular life sciences : CMLS · 2013Review
- Endoplasmic reticulum glycoprotein quality control regulates CD1d assembly and CD1d-mediated antigen presentation.The Journal of biological chemistry · 2013Article
- Role for lysosomal phospholipase A2 in iNKT cell-mediated CD1d recognition.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Multiple functions of microsomal triglyceride transfer protein.Nutrition & metabolism · 2012Article
- Critical role for invariant chain in CD1d-mediated selection and maturation of Vα14-invariant NKT cells.Immunology letters · 2011Article
- A central role for transcription factor C/EBP-beta in regulating CD1d gene expression in human keratinocytes.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Endosomal processing for antigen presentation mediated by CD1 and Class I major histocompatibility complex: roads to display or destruction.Immunology · 2009Review
- Natural lipid ligands associated with human CD1d targeted to different subcellular compartments.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Ig-like transcript 4 inhibits lipid antigen presentation through direct CD1d interaction.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Microsomal triglyceride transfer protein (MTP) is an endoplasmic reticulum (ER)-resident lipid transfer protein involved in the biosynthesis and lipid loading of apolipoprotein B. MTP was recently suggested to directly regulate the biosynthesis of the MHC I-like, lipid antigen presenting molecule CD1d, based on coprecipitation experiments and lipid loading assays. However, we found that the major impact of MTP deficiency occurred distal to the ER and Golgi compartments. Thus, although the rates of CD1d biosynthesis, glycosylation maturation, and internalization from the cell surface were preserved, the late but essential stage of recycling from lysosome to plasma membrane was profoundly impaired. Likewise, functional experiments indicated defects of CD1d-mediated lipid presentation in the lysosome but not in the secretory pathway. These intriguing findings suggest a novel, unexpected role of MTP at a late stage of CD1d trafficking in the lysosomal compartment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.