ArticleGut1992
Increased concentrations of interleukin 1 beta, interleukin-2, and soluble interleukin-2 receptors in endoscopical mucosal biopsy specimens with active inflammatory bowel disease.
Article in Gut, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 169 citations in OpenAlex.
- A simple filter-paper technique allows detection of mucosal cytokine levels in vivo in ulcerative colitis. Interleukin-1 and interleukin-1-receptor antagonist.Digestive diseases and sciences · 1996Trial
- Mucosal Epithelial Jak Kinases in Health and Diseases.Mediators of inflammation · 2021Review
- Review
- Identification of novel mRNAs and lncRNAs associated with mouse experimental colitis and human inflammatory bowel disease.American journal of physiology. Gastrointestinal and liver physiology · 2018Article
- Role of serotonin on the intestinal mucosal immune response to stress-induced diarrhea in weaning mice.BMC gastroenterology · 2017Article
- Selective modulation of autophagy, innate immunity, and adaptive immunity by small molecules.ACS chemical biology · 2013Article
- Interleukin-1 associations in inflammatory bowel disease and the enteropathic seronegative spondylarthritis.Auto- immunity highlights · 2013Article
- Plasma cytokine profiling in sibling pairs discordant for autism spectrum disorder.Journal of neuroinflammation · 2013Article
- IL-1β suppresses innate IL-25 and IL-33 production and maintains helminth chronicity.PLoS pathogens · 2013Article
- Molecular mechanism of interleukin-2-induced mucosal homeostasis.American journal of physiology. Cell physiology · 2012Article
- Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease.Inflammatory bowel diseases · 2008Article
- Increased cytokine transcripts in pouchitis reflect the degree of inflammation but not the underlying entity.International journal of colorectal disease · 2006Article
- Human colon carcinomas constitutively express and shed type II IL-1 receptor, an IL-1 antagonist.Digestive diseases and sciences · 2003Article
- Rate of occurrence and pathogenic effect of enteroaggregative Escherichia coli virulence factors in international travelers.Journal of clinical microbiology · 2002Article
- Murine monoclonal anti-tNF antibody administration has a beneficial effect on inflammatory bowel disease that develops in IL-10 knockout mice.Digestive diseases and sciences · 2002Article
- The proportion of Th1 cells, which prevail in gut mucosa, is decreased in inflammatory bowel syndrome.Clinical and experimental immunology · 2001Article
- Article
- Neuroendocrine changes in colon of mice with a disrupted IL-2 gene.Clinical and experimental immunology · 2000Article
- Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Concentrations of interleukin-1 beta (IL-1 beta), interleukin-2 (IL-2), and soluble IL-2 receptors (sIL-2R) were determined by enzyme linked immunosorbent assays (ELISA) in supernatants of sonicated endoscopical mucosal biopsy specimens from 31 patients with inflammatory bowel disease and 19 controls. IL-1 beta was detected in 53% of the patient supernatants (p = 0.0001), IL-2 in 35% (p = 0.0031), compared with none of the controls. Soluble IL-2R was present in 55% and 26% of the specimens, respectively (p = 0.07). The concentrations of IL-1 beta (p = 0.00015), IL-2 (p = 0.0019), and sIL-2R (p = 0.0073) were highest in the most inflamed biopsy specimens, compared with less inflamed specimens and controls. There were no significant differences in IL-1 beta, IL-2, and sIL-2R concentrations between ulcerative colitis (16) and Crohn's disease patients (15). The results suggest that enhanced cellular immunity operates in vivo at the mucosal level in active inflammatory bowel disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.