ReviewExperientia1992
The early and late processing of lysosomal enzymes: proteolysis and compartmentation.
Review in Experientia, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 154 citations in OpenAlex.
- A kaleidoscopic view of extracellular vesicles in lysosomal storage disorders.Extracellular vesicles and circulating nucleic acids · 2022Review
- Biodegradable polyethylene glycol hydrogels for sustained release and enhanced stability of rhGALNS enzyme.Drug delivery and translational research · 2020Article
- Adeno-associated viral gene therapy for mucopolysaccharidoses exhibiting neurodegeneration.Journal of molecular medicine (Berlin, Germany) · 2017Review
- Proteolytic Systems in Milk: Perspectives on the Evolutionary Function within the Mammary Gland and the Infant.Journal of mammary gland biology and neoplasia · 2015Review
- Arylsulfatase K, a novel lysosomal sulfatase.The Journal of biological chemistry · 2013Article
- Dysfunction of autophagy participates in vacuole formation and cell death in cells replicating hepatitis C virus.Journal of virology · 2011Article
- Characterization of the biosynthesis, processing and kinetic mechanism of action of the enzyme deficient in mucopolysaccharidosis IIIC.PloS one · 2011Article
- Initial insight into the function of the lysosomal 66.3 kDa protein from mouse by means of X-ray crystallography.BMC structural biology · 2009Article
- Prolactin promotes the secretion of active cathepsin D at the basal side of rat mammary acini.Endocrinology · 2008Article
- Endolysosomal proteolysis and its regulation.The Biochemical journal · 2002Review
- Enzymatic reduction of disulfide bonds in lysosomes: characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT).Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Properties of soluble fusions between mammalian aspartic proteinases and bacterial maltose-binding protein.Journal of protein chemistry · 1999Article
- Transport of human lysosomal neuraminidase to mature lysosomes requires protective protein/cathepsin A.The EMBO journal · 1998Article
- Expression, purification and characterization of recombinant caprine N-acetylglucosamine-6-sulphatase.The Biochemical journal · 1997Article
- The fates of proteins in cells.Die Naturwissenschaften · 1995Review
- Protein trafficking in kinetoplastid protozoa.Microbiological reviews · 1995Review
- Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells.The EMBO journal · 1995Article
- Physiological functions of endosomal proteolysis.The Biochemical journal · 1995Review
- Mitogenic function of human procathepsin D: the role of the propeptide.The Biochemical journal · 1994Article
- Two crystal structures for cathepsin D: the lysosomal targeting signal and active site.The EMBO journal · 1993Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lysosomal enzymes are subjected to a number of modifications including carbohydrate restructuring and proteolytic maturation. Some of these reactions support lysosomal targeting, others are necessary for activation or keeping the enzyme inactive before being segregated, while still others may be adventitious. The non-segregated fraction of the enzyme is secreted and can be isolated from the medium. It is considered that the secreted lysosomal enzymes fulfill certain physiological and pathophysiological roles. By comparing the secreted and the intracellular enzymes it is possible to distinguish between the reactions that occur before and after the segregation. In this review the reactions that may influence the segregation are referred to as the early processing and those characteristic for the enzymes isolated from lysosomal compartments as the late processing. The early processing is characterized mainly by modifications of carbohydrate side chains. In the late processing, proteolytic fragmentation represents the most conspicuous changes. The review focuses on the compartmentation of the reactions and the proteolytic fragmentation of lysosomal enzyme precursors. While a plethora of proteolytic reactions are involved, our knowledge of the proteinases responsible for the particular maturation reactions remains very limited. The review points also to work with cells from patients affected with lysosomal storage disorders, which contributed to our understanding of the lysosomal apparatus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.