ArticleEuropean archives of psychiatry and clinical neuroscience2007
Adult hippocampal neurogenesis and aging.
Article in European archives of psychiatry and clinical neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 138 citations in OpenAlex.
- Study protocol: a randomised controlled trial of the effects of a multi-modal exercise program on cognition and physical functioning in older women.BMC geriatrics · 2012Trial
- Independent and joint associations of psychological resilience and social support with cognitive impairment among middle-aged and older Chinese adults.Aging clinical and experimental research · 2026Article
- (Re)building the nervous system: A review of neuron-glia interactions from development to disease.Journal of neurochemistry · 2025Review
- Caloric restriction mimetics improve gut microbiota: a promising neurotherapeutics approach for managing age-related neurodegenerative disorders.Biogerontology · 2024Review
- Review
- Impact of Gut Microbiota in Brain Ageing: Polyphenols as Beneficial Modulators.Antioxidants (Basel, Switzerland) · 2023Review
- Steroid hormones: risk and resilience in women's Alzheimer disease.Frontiers in aging neuroscience · 2023Review
- Longterm Increased S100B Enhances Hippocampal Progenitor Cell Proliferation in a Transgenic Mouse Model.International journal of molecular sciences · 2022Article
- Review
- Microbiota-Gut-Brain Axis Regulation of Adult Hippocampal Neurogenesis.Brain plasticity (Amsterdam, Netherlands) · 2022Review
- Inflammation and Insulin Resistance as Risk Factors and Potential Therapeutic Targets for Alzheimer's Disease.Frontiers in neuroscience · 2021Review
- Effectiveness of Cognitive Interventions in Older Adults: A Review.European journal of investigation in health, psychology and education · 2020Review
- Chrysin Protects against Memory and Hippocampal Neurogenesis Depletion in D-Galactose-Induced Aging in Rats.Nutrients · 2020Article
- Neuroimmune and epigenetic mechanisms underlying persistent loss of hippocampal neurogenesis following adolescent intermittent ethanol exposure.Current opinion in pharmacology · 2020Review
- Born this way: Hippocampal neurogenesis across the lifespan.Aging cell · 2019Review
- The distribution of serotonergic nerve on the hippocampus of the fruit bats (Veterinary world · 2019Article
- Adult Neurogenesis, Glia, and the Extracellular Matrix.Cell stem cell · 2019Review
- Early compensatory responses against neuronal injury: A new therapeutic window of opportunity for Alzheimer's Disease?CNS neuroscience & therapeutics · 2019Review
- Roles and functions of Atp6ap2 in the brain.Neural regeneration research · 2018Review
- Regulation and function of neurogenesis in the adult mammalian hypothalamus.Progress in neurobiology · 2018Review
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The demographic changes in the foreseeable future stress the need for research on successful cognitive aging. Advancing age constitutes a primary risk factor for disease of the central nervous system most notably neurodegenerative disorders. The hippocampus is one of the brain regions that is prominently affected by neurodegeneration and functional decline even in what is still considered "normal aging". Plasticity is the basis for how the brain adapts to changes over time. The discovery of adult hippocampal neurogenesis has added a whole new dimension to research on structural plasticity in the adult and aging hippocampus. In this article, we briefly summarize and discuss recent findings on the regulation of adult neurogenesis with relevance to aging. Aging is an important co-variable for many regulatory mechanisms affecting adult neurogenesis but so far, only few studies have specifically addressed this interaction. We hypothesize that adult neurogenesis contributes to a neural reserve, i.e. the maintained potential for structural plasticity that allows compensation in situations of functional losses with aging. As such we propose that adult neurogenesis might contribute to the structural correlates of successful aging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.