ArticleJournal of neural transmission (Vienna, Austria : 1996)2007
Plasma amino acids and neopterin in healthy persons with Down's syndrome.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07047963 (Neuropsychological Evaluation in Intellectual Disability), which is not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neuropsychological Evaluation in Intellectual Disability
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Meta-analysis of metabolites involved in bioenergetic pathways reveals a pseudohypoxic state in Down syndrome.Molecular medicine (Cambridge, Mass.) · 2020Pooled it
- Pooled it
- Optimization and Validation of Plasma-Based Assay for Detection and Quantification of Monoamine Neurotransmitter Metabolites Using LC-MS/MS.ACS omega · 2026Article
- Cyanide overproduction impairs cellular bioenergetics in Down syndrome.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Role of cystathionine-β-synthase and hydrogen sulfide in down syndrome.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Charting the future: current and future directions in translational research for individuals with Down syndrome.Journal of neurodevelopmental disorders · 2025Review
- Exploring peripheral fluid biomarkers for early detection of Alzheimer's disease in Down syndrome: A literature review.Heliyon · 2025Review
- Pediatric Population with Down Syndrome: Obesity and the Risk of Cardiovascular Disease and Their Assessment Using Omics Techniques-Review.Biomedicines · 2022Review
- Phenotype microarrays reveal metabolic dysregulations of neurospheres derived from embryonic Ts1Cje mouse model of Down syndrome.PloS one · 2020Article
- Effect of blood contamination of cerebrospinal fluid on amino acids, biogenic amines, pterins and vitamins.Fluids and barriers of the CNS · 2019Article
- Alterations in the Serotonin and Dopamine Pathways by Cystathionine Beta Synthase Overexpression in Murine Brain.Molecular neurobiology · 2019Article
- Plasma and urinary metabolomic profiles of Down syndrome correlate with alteration of mitochondrial metabolism.Scientific reports · 2018Article
- Clinical aspects and biomarkers of Alzheimer's disease in Down syndrome.Free radical biology & medicine · 2018Review
- Monoaminergic impairment in Down syndrome with Alzheimer's disease compared to early-onset Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2018Article
- Red blood cell metabolism in Down syndrome: hints on metabolic derangements in aging.Blood advances · 2017Article
- Aging rather than aneuploidy affects monoamine neurotransmitters in brain regions of Down syndrome mouse models.Neurobiology of disease · 2017Article
- Urinary biomarkers and obstructive sleep apnea in patients with Down syndrome.Sleep medicine · 2017Article
- Acute Regression in Young People with Down Syndrome.Brain sciences · 2017Article
- Cognitive ability in Down syndrome and its relationship to urinary neopterin, a marker of activated cellular immunity.Neuroscience letters · 2017Article
- Memory decline in Down syndrome and its relationship to iPF2alpha, a urinary marker of oxidative stress.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In persons with Down's syndrome (DS) immunological abnormalities as well as hypothyroidism and Alzheimer type dementia are frequently observed. In addition, the activity of the enzyme cystathionine beta-synthase (CBS) is over-expressed which results in an altered homocysteine metabolism. In the present study, 48 older healthy DS persons without signs of dementia, psychiatric or somatic comorbidity and free of medication were analyzed for plasma levels of amino acids, neopterin and monoaminergic metabolites. Data were compared with those obtained from age and sex matched healthy controls. It was found that the spectrum of amino acids showed widespread differences in that levels of nearly all essential amino acids were lower in DS patients as compared to healthy controls. In addition, a significantly lower methionine and higher taurine concentration were observed which is in accordance with a disturbed homocysteine metabolism. With respect to the monoamine metabolites, the concentration of 5-hydroxyindoleacetic acid was not altered whereas that of homovanillic acid was significantly increased. Finally, the concentration of the immune activation marker neopterin was increased in persons with DS. It is concluded that healthy DS persons of older age show extensive biochemical abnormalities suggesting a compromised homocysteine metabolism, an activated cell-mediated immune response and an enhanced turnover of dopamine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.