ArticleSystems & control letters2006
Positive feedback may cause the biphasic response observed in the chemoattractant-induced response of Dictyostelium cells.
Article in Systems & control letters, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Cumulative dose responses for adapting biological systems.Journal of the Royal Society, Interface · 2025Article
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- Protein-protein complexes can undermine ultrasensitivity-dependent biological adaptation.Journal of the Royal Society, Interface · 2023Article
- Ultrasensitivity and bistability in covalent-modification cycles with positive autoregulation.Proceedings. Mathematical, physical, and engineering sciences · 2021Article
- PID Control as a Process of Active Inference with Linear Generative Models.Entropy (Basel, Switzerland) · 2019Article
- Non-monotonic Response to Monotonic Stimulus: Regulation of Glyoxylate Shunt Gene-Expression Dynamics in Mycobacterium tuberculosis.PLoS computational biology · 2016Article
- Fundamental limitation of the instantaneous approximation in fold-change detection models.IET systems biology · 2015Article
- Comparison of adaptation motifs: temporal, stochastic and spatial responses.IET systems biology · 2014Article
- Building robust functionality in synthetic circuits using engineered feedback regulation.Current opinion in biotechnology · 2013Review
- Actin cytoskeleton of chemotactic amoebae operates close to the onset of oscillations.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Open cascades as simple solutions to providing ultrasensitivity and adaptation in cellular signaling.Physical biology · 2011Article
- Article
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Authors and funding
2 authors.
Funding
Abstract
After stimulation by chemoattractant, Dictyostelium cells exhibit a rapid response. The concentrations of several intracellular proteins rise rapidly reaching their maximum levels approximately 5-10 seconds, after which they return to prestimulus levels. This response, which is found in many other chemotaxing cells, is an example of a step disturbance rejection, a process known to biologists as perfect adaptation. Unlike other cells, however, the initial first peak observed in the chemoattractant-induced response of Dictyostelium cells is then followed by a slower, smaller phase peaking approximately one to two minutes after the stimulus. Until recently, the nature of this biphasic response has been poorly understood. Moreover, the origin for the second phase is unknown. In this paper we conjecture the existence of a feedback path between the response and stimulus. Using a mathematical model of the chemoattractant-induced response in cells, and standard tools from control engineering, we show that positive feedback may elicit this second peak.
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Registered trials
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