ArticleThe EMBO journal1992
Behavioral and molecular analyses suggest that circadian output is disrupted by disconnected mutants in D. melanogaster.
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 88 citations in OpenAlex.
- Day-night gene expression reveals circadian geneProceedings. Biological sciences · 2024Article
- The zebrafish period2 protein positively regulates the circadian clock through mediation of retinoic acid receptor (RAR)-related orphan receptor α (Rorα).The Journal of biological chemistry · 2015Article
- Circadian clock gene expression in the coral Favia fragum over diel and lunar reproductive cycles.PloS one · 2011Article
- A role for microRNAs in the Drosophila circadian clock.Genes & development · 2009Article
- The neuropeptide PDF acts directly on evening pacemaker neurons to regulate multiple features of circadian behavior.PLoS biology · 2009Article
- Functional analysis of circadian pacemaker neurons in Drosophila melanogaster.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Disruption of Cryptochrome partially restores circadian rhythmicity to the arrhythmic period mutant of Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Drosophila free-running rhythms require intercellular communication.PLoS biology · 2003Article
- A recessive mutant of Drosophila Clock reveals a role in circadian rhythm amplitude.The EMBO journal · 2003Article
- The extraretinal eyelet of Drosophila: development, ultrastructure, and putative circadian function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Sequential nuclear accumulation of the clock proteins period and timeless in the pacemaker neurons of Drosophila melanogaster.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Drosophila photoreceptors contain an autonomous circadian oscillator that can function without period mRNA cycling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Drosophila melanogaster deficient in protein kinase A manifests behavior-specific arrhythmia but normal clock function.Molecular and cellular biology · 1997Article
- Article
- A novel circadianly expressed Drosophila melanogaster gene dependent on the period gene for its rhythmic expression.The EMBO journal · 1996Article
- Neurotransmitters regulate rhythmic size changes amongst cells in the fly's optic lobe.Journal of comparative physiology. A, Sensory, neural, and behavioral physiology · 1996Article
- Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless.The EMBO journal · 1995Article
- Characterization of linne, a new autosomal eclosion rhythm mutant in Drosophila subobscura.Behavior genetics · 1993Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Mutations in the disconnected (disco) gene act to disrupt neural cell patterning in the Drosophila visual system. These mutations also affect adult locomotor activity rhythms, as disco flies are arrhythmic under conditions of constant darkness (DD). To determine the state of the circadian pacemaker in disco mutants, we constructed with pers double mutants (a short period allele of the period gene) and assayed their behavioral rhythms in light-dark cycles (LD), and their biochemical rhythms of period gene expression under both LD and DD conditions. The results demonstrate that disco flies are rhythmic, indicating that they have an active circadian pacemaker that can be entrained by light. They also suggest that disco mutants block or interfere with elements of the circadian system located between the central pacemaker and its outputs that mediate overt rhythms.
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