ArticleThe Plant cell2007
Genome-wide analysis of the RNA-DEPENDENT RNA POLYMERASE6/DICER-LIKE4 pathway in Arabidopsis reveals dependency on miRNA- and tasiRNA-directed targeting.
Article in The Plant cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 213 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
213 citing papers in PubMed, 1 synthesis or guideline pooled it, 410 citations in OpenAlex.
- The role of microRNAs in responses to drought and heat stress in peanut (Arachis hypogaea).The plant genome · 2023Pooled it
- A conserved small RNA-generating gene cluster undergoes sequence diversification and contributes to plant immunity.Nature communications · 2026Article
- Article
- syn-tasiRnas targeting the coat protein of potato virus Y confer antiviral resistance inPlant signaling & behavior · 2024Article
- Engineering VIGS Vectors by Modifying Movement Proteins of the 30K Family.Biotechnology journal · 2024Article
- Integrated Transcriptome and sRNAome Analysis Reveals the Molecular Mechanisms ofInternational journal of molecular sciences · 2024Article
- The biogenesis, regulation and functions of transitive siRNA in plants.Acta biochimica et biophysica Sinica · 2024Review
- Genome-wide identification and in silico characterization of major RNAi gene families in date palm (Phoenix dactylifera).BMC genomic data · 2024Article
- The plant siRNA landscape.The Plant cell · 2024Review
- Identification of Arabidopsis thaliana small RNAs responsive to the fungal pathogen Botrytis cinerea at an early stage of interaction.PloS one · 2024Article
- Phased secondary small interfering RNAs inNAR genomics and bioinformatics · 2023Article
- Regulation of plant immunity via small RNA-mediated control of NLR expression.Journal of experimental botany · 2023Article
- Strategies for Engineering Virus Resistance in Potato.Plants (Basel, Switzerland) · 2023Review
- The N-terminal extension of Arabidopsis ARGONAUTE 1 is essential for microRNA activities.PLoS genetics · 2023Article
- Role of miRNAs in sucrose stress response, reactive oxygen species, and anthocyanin biosynthesis inFrontiers in plant science · 2023Article
- Identification and characterization of miRNAs and PHAS loci related to the early development of the embryo and endosperm in Fragaria × ananassa.BMC genomics · 2022Article
- Identification and functional annotation of long intergenic non-coding RNAs in Brassicaceae.The Plant cell · 2022Article
- Identification of genetic loci in lettuce mediating quantitative resistance to fungal pathogens.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- TRUEE; a bioinformatic pipeline to define the functional microRNA targetome of Arabidopsis.The Plant journal : for cell and molecular biology · 2022Article
- TOPLESS in the regulation of plant immunity.Plant molecular biology · 2022Review
153 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Posttranscriptional RNA silencing of many endogenous transcripts, viruses, and transgenes involves the RNA-DEPENDENT RNA POLYMERASE6/DICER-LIKE4 (RDR6/DCL4)-dependent short interfering RNA (siRNA) biogenesis pathway. Arabidopsis thaliana contains several families of trans-acting siRNAs (tasiRNAs) that form in 21-nucleotide phased arrays through the RDR6/DCL4-dependent pathway and that negatively regulate target transcripts. Using deep sequencing technology and computational approaches, the phasing patterns of known tasiRNAs and tasiRNA-like loci from across the Arabidopsis genome were analyzed in wild-type plants and silencing-defective mutants. Several gene transcripts were found to be routed through the RDR6/DCL4-dependent pathway after initial targeting by one or multiple miRNAs or tasiRNAs, the most conspicuous example of which was an expanding clade of genes encoding pentatricopeptide repeat (PPR) proteins. Interestingly, phylogenetic analysis using Populus trichocarpa revealed evidence for small RNA-mediated regulatory mechanisms within a similarly expanded group of PPR genes. We suggest that posttranscriptional silencing mechanisms operate on an evolutionary scale to buffer the effects of rapidly expanding gene families.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.