ArticleBiophysical journal2007
Pore formation in a lipid bilayer under a tension ramp: modeling the distribution of rupture tensions.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 33 citations in OpenAlex.
- Advancements in Engineering Planar Model Cell Membranes: Current Techniques, Applications, and Future Perspectives.Nanomaterials (Basel, Switzerland) · 2024Review
- Systematic design of cell membrane coating to improve tumor targeting of nanoparticles.Nature communications · 2022Article
- Switching Cytolytic Nanopores into Antimicrobial Fractal Ruptures by a Single Side Chain Mutation.ACS nano · 2021Article
- Artificial Lipid Membranes: Past, Present, and Future.Membranes · 2017Review
- Electroelastic coupling between membrane surface fluctuations and membrane-embedded charges: continuum multidielectric treatment.The Journal of chemical physics · 2010Article
- Mechanosensitive closed-closed transitions in large membrane proteins: osmoprotection and tension damping.Biophysical journal · 2009Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rupture of fluid membrane vesicles with a steady ramp of micropipette suction has been shown to produce a distribution of breakage tensions, with a mean that rises rapidly with tension rate. Starting from a lattice model that incorporates the essential features of the lipid bilayers held together with hydrophobic forces, and developing it to handle varying tension rates, we reproduce the main features of the experimental results. In essence, we show that the rupture kinetics are driven by the nucleation and growth of pores, with two limiting kinetics-growth-limited and nucleation-limited. The model has been extended to address the role of peptides in solution that can adsorb and insert themselves into the bilayer. At concentrations below those required to spontaneously rupture the membrane, the effect of the peptides is to lower the rupture tensions systematically for all tension rates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.