ArticleToxicology and applied pharmacology2007
Arsenite and insulin exhibit opposing effects on epidermal growth factor receptor and keratinocyte proliferative potential.
Article in Toxicology and applied pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- Cutaneous Malignancy due to Arsenicosis in Bangladesh: 12-Year Study in Tertiary Level Hospital.BioMed research international · 2018Trial
- Arsenic exposure in drinking water reduces Lgr5 and secretory cell marker gene expression in mouse intestines.Toxicology and applied pharmacology · 2021Article
- Chronic and acute arsenic exposure enhance EGFR expression via distinct molecular mechanisms.Toxicology in vitro : an international journal published in association with BIBRA · 2020Article
- Arsenic Stimulates Myoblast Mitochondrial Epidermal Growth Factor Receptor to Impair Myogenesis.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Deducing signaling pathways from parallel actions of arsenite and antimonite in human epidermal keratinocytes.Scientific reports · 2020Article
- Article
- Metal carcinogen exposure induces cancer stem cell-like property through epigenetic reprograming: A novel mechanism of metal carcinogenesis.Seminars in cancer biology · 2019Review
- Cancer Stem-Like Cells Accumulated in Nickel-Induced Malignant Transformation.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- Parallel responses of human epidermal keratinocytes to inorganic SbIII and AsIII.Environmental chemistry (Collingwood, Vic.) · 2016Article
- The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis.Carcinogenesis · 2015Review
- Arsenite suppression of BMP signaling in human keratinocytes.Toxicology and applied pharmacology · 2013Article
- Chronic exposure of renal stem cells to inorganic arsenic induces a cancer phenotype.Chemical research in toxicology · 2013Article
- Article
- Overabundance of putative cancer stem cells in human skin keratinocyte cells malignantly transformed by arsenic.Toxicological sciences : an official journal of the Society of Toxicology · 2012Article
- Arsenic, stem cells, and the developmental basis of adult cancer.Toxicological sciences : an official journal of the Society of Toxicology · 2011Article
- Induction of human squamous cell-type carcinomas by arsenic.Journal of skin cancer · 2011Article
- Carcinogenic effects of "whole-life" exposure to inorganic arsenic in CD1 mice.Toxicological sciences : an official journal of the Society of Toxicology · 2011Article
- Cancer in experimental animals exposed to arsenic and arsenic compounds.Critical reviews in toxicology · 2010Review
- Arsenic-specific stem cell selection during malignant transformation.Journal of the National Cancer Institute · 2010Article
- Opposing actions of insulin and arsenite converge on PKCdelta to alter keratinocyte proliferative potential and differentiation.Molecular carcinogenesis · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Previous work has suggested that arsenic exposure contributes to skin carcinogenesis by preserving the proliferative potential of human epidermal keratinocytes, thereby slowing the exit of putative target stem cells into the differentiation pathway. To find a molecular basis for this action, present work has explored the influence of arsenite on keratinocyte responses to epidermal growth factor (EGF). The ability of cultured keratinocytes to found colonies upon passaging several days after confluence was preserved by arsenite and EGF in an additive fashion, but neither was effective when the receptor tyrosine kinase activity was inhibited. Arsenite prevented the loss of EGF receptor protein and phosphorylation of tyrosine 1173, preserving its capability to signal. The level of nuclear beta-catenin was higher in cells treated with arsenite and EGF in parallel to elevated colony forming ability, and expression of a dominant negative beta-catenin suppressed the increase in both colony forming ability and yield of putative stem cells induced by arsenite and EGF. As judged by expression of three genes regulated by beta-catenin, this transcription factor had substantially higher activity in the arsenite/EGF-treated cells. Trivalent antimony exhibited the same effects as arsenite. A novel finding is that insulin in the medium induced the loss of EGF receptor protein, which was largely prevented by arsenite exposure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.