ArticleBiochimica et biophysica acta2007
The direct p53 target gene, FLJ11259/DRAM, is a member of a novel family of transmembrane proteins.
Article in Biochimica et biophysica acta, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- A novel diabetic foot ulcer diagnostic model: identification and analysis of genes related to glutamine metabolism and immune infiltration.BMC genomics · 2024Article
- Knockdown of Transmembrane Protein 150A (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2022Article
- DRAM1 increases the secretion of PKM2-enriched EVs from hepatocytes to promote macrophage activation and disease progression in ALD.Molecular therapy. Nucleic acids · 2022Article
- DRAM1 regulates autophagy and cell proliferation via inhibition of the phosphoinositide 3-kinase-Akt-mTOR-ribosomal protein S6 pathway.Cell communication and signaling : CCS · 2019Article
- miR-199a-5p Represses Protective Autophagy and Overcomes Chemoresistance by Directly Targeting DRAM1 in Acute Myeloid Leukemia.Journal of oncology · 2019Article
- The fourth transmembrane helix is important for DRAM function.Acta biochimica et biophysica Sinica · 2016Article
- Autophagy in Diabetic Retinopathy.Current neuropharmacology · 2016Review
- N-Myc and STAT Interactor regulates autophagy and chemosensitivity in breast cancer cells.Scientific reports · 2015Article
- DRAM1 protects neuroblastoma cells from oxygen-glucose deprivation/reperfusion-induced injury via autophagy.International journal of molecular sciences · 2014Article
- Effects of damage-regulated autophagy regulator gene on the SGC7901 human gastric cancer cell line.Oncology letters · 2014Article
- Autophagy is induced through the ROS-TP53-DRAM1 pathway in response to mitochondrial protein synthesis inhibition.Autophagy · 2012Article
- The expression of damage-regulated autophagy modulator 2 (DRAM2) contributes to autophagy induction.Molecular biology reports · 2012Article
- Serum starvation induces DRAM expression in liver cancer cells via histone modifications within its promoter locus.PloS one · 2012Article
- DRAM-1 encodes multiple isoforms that regulate autophagy.Autophagy · 2012Article
- Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells.The Journal of biological chemistry · 2011Article
- High DNA methyltransferase 3B expression mediates 5-aza-deoxycytidine hypersensitivity in testicular germ cell tumors.Cancer research · 2009Article
- Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Homeostatic functions of the p53 tumor suppressor: regulation of energy metabolism and antioxidant defense.Seminars in cancer biology · 2009Review
- Dissection of a complex transcriptional response using genome-wide transcriptional modelling.Molecular systems biology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The tumor suppressor p53 regulates diverse biological processes primarily via activation of downstream target genes. Even though many p53 target genes have been described, the precise mechanisms of p53 biological actions are uncertain. In previous work we identified by microarray analysis a candidate p53 target gene, FLJ11259/DRAM. In this report we have identified three uncharacterized human proteins with sequence homology to FLJ11259, suggesting that FLJ11259 is a member of a novel family of proteins with six transmembrane domains. Several lines of investigation confirm FLJ11259 is a direct p53 target gene. p53 siRNA prevented cisplatin-mediated up-regulation of FLJ11259 in NT2/D1 cells. Likewise in HCT116 p53+/+ cells and MCF10A cells, FLJ11259 is induced by cisplatin treatment but to a much lesser extent in isogenic p53-suppressed cells. A functional p53 response element was identified 22.3 kb upstream of the first coding exon of FLJ11259 and is shown to be active in reporter assays. In addition, chromatin immunoprecipitation assays indicate that p53 binds directly to this element in vivo and that binding is enhanced following cisplatin treatment. Confocal microscopy showed that an FLJ-GFP fusion protein localizes mainly in a punctate pattern in the cytoplasm. Overexpression studies in Cos-7, Saos2, and NT2/D1 cells suggest that FLJ11259 is associated with increased clonal survival. In summary, we have identified FLJ11259/DRAM as a p53-inducible member of a novel family of transmembrane proteins. FLJ11259/DRAM may be an important modulator of p53 responses in diverse tumor types.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.