ArticleVirology2007
Differences in tropism and pH dependence for glycoproteins from the Clade B1 arenaviruses: implications for receptor usage and pathogenicity.
Article in Virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- TRIM2, a novel member of the antiviral family, limits New World arenavirus entry.PLoS biology · 2019Article
- New World Arenavirus Biology.Annual review of virology · 2017Review
- Novel Arenavirus Entry Inhibitors Discovered by Using a Minigenome Rescue System for High-Throughput Drug Screening.Journal of virology · 2015Article
- IFITM-Family Proteins: The Cell's First Line of Antiviral Defense.Annual review of virology · 2014Article
- Nonhuman transferrin receptor 1 is an efficient cell entry receptor for Ocozocoautla de Espinosa virus.Journal of virology · 2013Article
- siRNA screen for genes that affect Junín virus entry uncovers voltage-gated calcium channels as a therapeutic target.Science translational medicine · 2013Article
- Drug discovery technologies and strategies for Machupo virus and other New World arenaviruses.Expert opinion on drug discovery · 2012Review
- Substitutions in the glycoprotein (GP) of the Candid#1 vaccine strain of Junin virus increase dependence on human transferrin receptor 1 for entry and destabilize the metastable conformation of GP.Journal of virology · 2011Article
- Junin virus infects mouse cells and induces innate immune responses.Journal of virology · 2011Article
- Machupo virus glycoprotein determinants for human transferrin receptor 1 binding and cell entry.PloS one · 2011Article
- Investigation of clade B New World arenavirus tropism by using chimeric GP1 proteins.Journal of virology · 2010Article
- The RING domain and the L79 residue of Z protein are involved in both the rescue of nucleocapsids and the incorporation of glycoproteins into infectious chimeric arenavirus-like particles.Journal of virology · 2009Article
- Host-species transferrin receptor 1 orthologs are cellular receptors for nonpathogenic new world clade B arenaviruses.PLoS pathogens · 2009Article
- Identification of a broad-spectrum arenavirus entry inhibitor.Journal of virology · 2008Article
- Viral infection and iron metabolism.Nature reviews. Microbiology · 2008Review
- Receptor use by the Whitewater Arroyo virus glycoprotein.Virology · 2008Article
- Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenaviruses.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- New world clade B arenaviruses can use transferrin receptor 1 (TfR1)-dependent and -independent entry pathways, and glycoproteins from human pathogenic strains are associated with the use of TfR1.Journal of virology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The Clade B lineage of the New World arenaviruses contains four viruses capable of causing severe hemorrhagic fevers in humans. Within this group, the B1 sub-lineage contains the pathogenic viruses Junin (JUNV) and Machupo (MACV), as well as the non-pathogenic Tacaribe virus (TCRV). In order to elucidate differences that may determine pathogenicity, we studied the entry pathways directed by the glycoproteins (GPs) from these related B1 viruses, using pseudotyped retroviral vectors and GP1 immunoadhesin constructs. Our data revealed variations in the efficiency with which different cell types could be transduced by B1 vectors, and this correlated with the ability of the immunoadhesins to bind to those cells. Interestingly, the tropism directed by the TCRV GP proved to be distinct from that of JUNV and MACV, in particular on lymphocyte cell lines. In addition, the GPs showed variations in their sensitivity to an inhibitor of endosome acidification, with the TCRV GP again being the outlier. Together these data suggest that more than one entry pathway can be used by these closely related viruses and that the ability to cause human disease may be highly dependent on receptor usage.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.