Evidence map›Paper›PMID 17397838›Full record

ReviewFEBS letters2007

Cellular functions of NSF: not just SNAPs and SNAREs.

Chunxia Zhao, John T Slevin, Sidney W Whiteheart

Open access · greenAbstract readReview
In one paragraph

Review in FEBS letters, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 135 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. The Ever-Expanding Influence of the Endothelial Nitric Oxide Synthase.Basic & clinical pharmacology & toxicology · 2025
    Review
  6. PEX1The Journal of biological chemistry · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Early Endosomes Act as Local Exocytosis Hubs to Repair Endothelial Membrane Damage.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  14. Analysis ofBioMed research international · 2023
    Article
  15. SNARE Proteins in Synaptic Vesicle Fusion.Advances in neurobiology · 2023
    Article
  16. Article
  17. mRNA Localization to the Endoplasmic Reticulum in Plant Endosperm Cells.International journal of molecular sciences · 2022
    Review
  18. Review
  19. Review
  20. Article

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Chunxia ZhaoDepartment of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, 741 South Limestone, BBSRB B261, Lexington, KY 40536, USA.
John T Slevin
Sidney W Whiteheart
University of Kentucky · US

Funding

MOLECULAR MECHANISMS OF PLATELET EXOCYTOSISR01HL056652 · NHLBI · UNIVERSITY OF KENTUCKY · PI WHITEHEART, SIDNEY WALDO · 1996 to 2019
$5.2M
Structure/Function of N-ethylmaleimide Sensitive FactorR01NS046242 · NINDS · UNIVERSITY OF KENTUCKY · PI WHITEHEART, SIDNEY WALDO · 2004 to 2007
$1.1M
NHLBI NIH HHS R01 HL056652NINDS NIH HHS NS046242NINDS NIH HHS R01 NS046242
6 · The paper itself

Abstract

N-ethylmaleimide sensitive factor (NSF) is an ATPases associated with various cellular activities protein (AAA), broadly required for intracellular membrane fusion. NSF functions as a SNAP receptor (SNARE) chaperone which binds, through soluble NSF attachment proteins (SNAPs), to SNARE complexes and utilizes the energy of ATP hydrolysis to disassemble them thus facilitating SNARE recycling. While this is a major function of NSF, it does seem to interact with other proteins, such as the AMPA receptor subunit, GluR2, and beta2-AR and is thought to affect their trafficking patterns. New data suggest that NSF may be regulated by transient post-translational modifications such as phosphorylation and nitrosylation. These new aspects of NSF function as well as its role in SNARE complex dynamics will be discussed.

Indexed as

AnimalsCytoskeletonModels, MolecularN-Ethylmaleimide-Sensitive ProteinsProtein BindingProtein ConformationSNARE ProteinsSoluble N-Ethylmaleimide-Sensitive Factor Attachment ProteinsTransport VesiclesN-Ethylmaleimide-Sensitive ProteinsSNARE ProteinsSoluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins

Identifiers

PMID17397838
PMCPMC1948069
OpenAlexW2122910625

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.