ArticleThe EMBO journal2007
Reconstruction of a pathway of antigen processing and class II MHC peptide capture.
Article in The EMBO journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 42 citations in OpenAlex.
- Lysosomes and lysosome-related organelles in immune responses.FEBS open bio · 2022Review
- BepiTBR: T-B reciprocity enhances B cell epitope prediction.iScience · 2022Article
- Protein structure shapes immunodominance in the CD4 T cell response to yellow fever vaccination.Scientific reports · 2017Article
- Creation of an engineered APC system to explore and optimize the presentation of immunodominant peptides of major allergens.Scientific reports · 2016Article
- Focused antibody response to influenza linked to antigenic drift.The Journal of clinical investigation · 2015Article
- Polarity protein Par3 controls B-cell receptor dynamics and antigen extraction at the immune synapse.Molecular biology of the cell · 2015Article
- The MHC class II cofactor HLA-DM interacts with Ig in B cells.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Are cases of mumps in vaccinated patients attributable to mismatches in both vaccine T-cell and B-cell epitopes?: An immunoinformatic analysis.Human vaccines & immunotherapeutics · 2014Article
- Pathways of antigen processing.Annual review of immunology · 2013Review
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- Article
- The endosome-lysosome pathway and information generation in the immune system.Biochimica et biophysica acta · 2012Review
- Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys.Nature medicine · 2010Article
- Editing antigen presentation: antigen transfer between human B lymphocytes and macrophages mediated by class A scavenger receptors.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- MHC class II molecules on the move for successful antigen presentation.The EMBO journal · 2008Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Endocytosed antigens are proteolytically processed and small amounts of peptides captured by class II MHC molecules. The details of antigen proteolysis, peptide capture and how destruction of T-cell epitopes is avoided are incompletely understood. Using the tetanus toxin antigen, we show that the introduction of 3-6 cleavage sites is sufficient to trigger a partially unfolded conformation able to bind to class II MHC molecules. The known locations of T-cell epitopes and protease cleavage sites predict that large domains of processed antigen (8-35 kDa) are captured under these conditions. Remarkably, when antigen is bound to the B-cell antigen receptor (BCR), processing can trigger a concerted 'hand-over' reaction whereby BCR-associated processed antigen is captured by neighbouring class II MHC molecules. Early capture of minimally processed antigen and confinement of the processing and class II MHC loading reaction to the membrane plane may improve the likelihood of T-cell epitope survival in the class II MHC pathway and may help explain the reciprocal relationships observed between B- and T-cell epitopes in many protein antigens and autoantigens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.