ArticleNucleic acids research2007
Quadruplex ligands may act as molecular chaperones for tetramolecular quadruplex formation.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Conformational Change in a Four-Tetrad DNA G-Quadruplex upon Intercalation of a Small-Molecule Ligand PyDH2.Angewandte Chemie (International ed. in English) · 2025Article
- Asymmetric distribution of G-quadruplex forming sequences in genomes of retroviruses.Scientific reports · 2025Article
- Iso-FRET: an isothermal competition assay to analyze quadruplex formation in vitro.Nucleic acids research · 2022Article
- Locking up the AS1411 Aptamer with a Flanking Duplex: Towards an Improved Nucleolin-Targeting.Pharmaceuticals (Basel, Switzerland) · 2021Article
- G-Quadruplex DNA and RNA.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Dominant Driving Forces in Human Telomere Quadruplex Binding-Induced Structural Alterations.Biophysical journal · 2015Article
- G-quadruplex DNA and ligand interaction in living cells using NMR spectroscopy.Chemical science · 2015Article
- G-quadruplexes as potential therapeutic targets for embryonal tumors.Molecules (Basel, Switzerland) · 2013Review
- Interaction of human telomeric DNA with N-methyl mesoporphyrin IX.Nucleic acids research · 2012Article
- Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death.Cellular and molecular life sciences : CMLS · 2012Article
- G4 motifs correlate with promoter-proximal transcriptional pausing in human genes.Nucleic acids research · 2011Article
- Structural insights into G-quadruplexes: towards new anticancer drugs.Future medicinal chemistry · 2010Review
- Arrangements of human telomere DNA quadruplex in physiologically relevant K+ solutions.Nucleic acids research · 2009Article
- Chiral metallo-supramolecular complexes selectively recognize human telomeric G-quadruplex DNA.Nucleic acids research · 2008Article
- Structural polymorphism of intramolecular quadruplex of human telomeric DNA: effect of cations, quadruplex-binding drugs and flanking sequences.Nucleic acids research · 2008Article
- Genomic distribution and functional analyses of potential G-quadruplex-forming sequences in Saccharomyces cerevisiae.Nucleic acids research · 2008Article
- End-stacking of copper cationic porphyrins on parallel-stranded guanine quadruplexes.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2007Article
- Quartets in G-major. The First International Meeting on Quadruplex DNA.EMBO reports · 2007Review
- First International Meeting on Quadruplex DNA.ACS chemical biology · 2007Article
- Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.Nucleic acids research · 2007Review
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
G-quadruplexes are a family of four-stranded DNA structures, stabilized by G-quartets, that form in the presence of monovalent cations. Efforts are currently being made to identify ligands that selectively bind to G-quadruplex motifs as these compounds may interfere with the telomere structure, telomere elongation/replication and proliferation of cancer cells. The kinetics of quadruplex-ligands interactions are poorly understood: it is not clear whether quadruplex ligands lock into the preformed structure (i.e. increase the lifetime of the structure by lowering the dissociation constant, k(off)) or whether ligands actively promote the formation of the complex and act as quadruplex chaperones by increasing the association constant, k(on). We studied the effect of a selective quadruplex ligand, a bisquinolinium pyridine dicarboxamide compound called 360A, to distinguish these two possibilities. We demonstrated that, in addition to binding to and locking into preformed quadruplexes, this molecule acted as a chaperone for tetramolecular complexes by acting on k(on). This observation has implications for in vitro and in vivo applications of quadruplexes and should be taken into account when evaluating the cellular responses to these agents.
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Registered trials
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